Heat Transfer in Biological Spherical Tissues during Hyperthermia of Magnetoma

SIMPLE SUMMARY: Heat transport in biological tissue is mediated through a variety of phenomenological processes, involving tissue heat exchange, blood-tissue convection, blood perfusion or advection and diffusion across microvascular beds, and metabolic heat production. In recent years, many physicians and engineers have taken an interest in applying computational and mathematical techniques to model biological systems. The objective of the current paper is to provide an analytical solution to the modified Pennes bioheat conduction equation with a single relaxation time. The suggested model is used to examine heat transport in biological tissues as an infinite concentric spherical region during magnetic fluid hyperthermia. This method is used to investigate the influence of heat generation through heat treatment on a skin tumor a spherical layered structure. The present model can explain the effect of different therapeutic approaches such as cryotherapy sessions, laser therapy, and physical occurrences including transfer, metabolism support, blood perfusion, and other similar treatments. ABSTRACT: Hyperthermia therapy is now being used to treat cancer. However, understanding the pattern of temperature increase in biological tissues during hyperthermia treatment is essential. In recent years, many physicians and engineers have studied the use of computational and mathematical models of heat transfer in biological systems. The rapid progress in computing technology has intrigued many researchers. Many medical procedures also use engineering techniques and mathematical modeling to ensure their safety and assess the risks involved. One such model is the modified Pennes bioheat conduction equation. This paper provides an analytical solution to the modified Pennes bioheat conduction equation with a single relaxation time by incorporating in it the (MGT) equation. The suggested model examines heat transport in biological tissues as forming an infinite concentric spherical region during magnetic fluid hyperthermia. To investigate thermal reactions caused by temperature shock, specifically the influence of heat generation through heat treatment on a skin tumor [AEGP9], the Laplace transformation, and numerical inverse transformation methods are used. This model was able to explain the effects of different therapeutic approaches such as cryotherapy sessions, laser therapy, and physical occurrences, transfer, metabolism support, and blood perfusion. Comparison of the numerical results of the suggested model with those in the literature confirmed the validity of the model’s numerical results.