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Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice

SIMPLE SUMMARY: Type 4 cAMP-phosphodiesterases (PDE4s) comprise a family of four isoenzymes, PDE4A to D, that hydrolyze and inactivate the second messenger cAMP. Non/PAN-selective PDE4 inhibitors, which inhibit all four PDE4 subtypes simultaneously, produce many promising therapeutic benefits, such...

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Detalles Bibliográficos
Autores principales:	Boyd, Abigail, Aragon, Ileana V., Rich, Justin, McDonough, Will, Oditt, Marianna, Irelan, Daniel, Fiedler, Edward, Abou Saleh, Lina, Richter, Wito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698290/ https://www.ncbi.nlm.nih.gov/pubmed/34943270 http://dx.doi.org/10.3390/biology10121355

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