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Rhodium(iii) catalyzed olefination and deuteration of tetrahydrocarbazole

The rhodium-catalyzed olefination and deuteration of tetrahydrocarbazoles in water with the aid of an N,N-dimethylcarbamoyl-protected group is presented. This olefination method features a broad substrate scope, good functional-group tolerance, and high efficiency in water. Practical applications of...

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Detalles Bibliográficos
Autores principales: Peng, Wan, Liu, Qiaohong, Yin, Fucheng, Shi, Cunjian, Ji, Limei, Qu, Lailiang, Wang, Cheng, Luo, Heng, Kong, Lingyi, Wang, Xiaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698316/
https://www.ncbi.nlm.nih.gov/pubmed/35423333
http://dx.doi.org/10.1039/d1ra00236h
Descripción
Sumario:The rhodium-catalyzed olefination and deuteration of tetrahydrocarbazoles in water with the aid of an N,N-dimethylcarbamoyl-protected group is presented. This olefination method features a broad substrate scope, good functional-group tolerance, and high efficiency in water. Practical applications of the protocol are illustrated by the synthesis of various evodiamine derivatives. As such, this environmentally friendly approach to directly modify natural products will attract much attention in academic and industrial research.