Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and lead to persistently elevated mutant peptide levels...

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Detalles Bibliográficos
Autores principales: Lieb, Andreas, Thaler, Germana, Fogli, Barbara, Trovato, Olga, Posch, Mitja Amon, Kaserer, Teresa, Zangrandi, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698333/
https://www.ncbi.nlm.nih.gov/pubmed/34944698
http://dx.doi.org/10.3390/biomedicines9121882

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