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Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends
Oxygen is the final electron acceptor in aerobic respiration, and a lack of oxygen can result in bioenergetic failure and cell death. Thus, administration of supplemental concentrations of oxygen to overcome barriers to tissue oxygen delivery (e.g., heart failure, lung disease, ischemia), can rescue...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698336/ https://www.ncbi.nlm.nih.gov/pubmed/34942982 http://dx.doi.org/10.3390/antiox10121879 |
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author | Mathias, Maxwell Chang, Jill Perez, Marta Saugstad, Ola |
author_facet | Mathias, Maxwell Chang, Jill Perez, Marta Saugstad, Ola |
author_sort | Mathias, Maxwell |
collection | PubMed |
description | Oxygen is the final electron acceptor in aerobic respiration, and a lack of oxygen can result in bioenergetic failure and cell death. Thus, administration of supplemental concentrations of oxygen to overcome barriers to tissue oxygen delivery (e.g., heart failure, lung disease, ischemia), can rescue dying cells where cellular oxygen content is low. However, the balance of oxygen delivery and oxygen consumption relies on tightly controlled oxygen gradients and compartmentalized redox potential. While therapeutic oxygen delivery can be life-saving, it can disrupt growth and development, impair bioenergetic function, and induce inflammation. Newborns, and premature newborns especially, have features that confer particular susceptibility to hyperoxic injury due to oxidative stress. In this review, we will describe the unique features of newborn redox physiology and antioxidant defenses, the history of therapeutic oxygen use in this population and its role in disease, and clinical trends in the use of therapeutic oxygen and mitigation of neonatal oxidative injury. |
format | Online Article Text |
id | pubmed-8698336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86983362021-12-24 Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends Mathias, Maxwell Chang, Jill Perez, Marta Saugstad, Ola Antioxidants (Basel) Review Oxygen is the final electron acceptor in aerobic respiration, and a lack of oxygen can result in bioenergetic failure and cell death. Thus, administration of supplemental concentrations of oxygen to overcome barriers to tissue oxygen delivery (e.g., heart failure, lung disease, ischemia), can rescue dying cells where cellular oxygen content is low. However, the balance of oxygen delivery and oxygen consumption relies on tightly controlled oxygen gradients and compartmentalized redox potential. While therapeutic oxygen delivery can be life-saving, it can disrupt growth and development, impair bioenergetic function, and induce inflammation. Newborns, and premature newborns especially, have features that confer particular susceptibility to hyperoxic injury due to oxidative stress. In this review, we will describe the unique features of newborn redox physiology and antioxidant defenses, the history of therapeutic oxygen use in this population and its role in disease, and clinical trends in the use of therapeutic oxygen and mitigation of neonatal oxidative injury. MDPI 2021-11-25 /pmc/articles/PMC8698336/ /pubmed/34942982 http://dx.doi.org/10.3390/antiox10121879 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mathias, Maxwell Chang, Jill Perez, Marta Saugstad, Ola Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends |
title | Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends |
title_full | Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends |
title_fullStr | Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends |
title_full_unstemmed | Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends |
title_short | Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends |
title_sort | supplemental oxygen in the newborn: historical perspective and current trends |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698336/ https://www.ncbi.nlm.nih.gov/pubmed/34942982 http://dx.doi.org/10.3390/antiox10121879 |
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