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Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems

Complement and coagulation are both key systems that defend the body from harm. They share multiple features and are similarly activated. They each play individual roles in the systemic circulation in physiology and pathophysiology, with significant crosstalk between them. Components from both syste...

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Autores principales: Berkowitz, Shani, Chapman, Joab, Dori, Amir, Gofrit, Shany Guly, Maggio, Nicola, Shavit-Stein, Efrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698364/
https://www.ncbi.nlm.nih.gov/pubmed/34944766
http://dx.doi.org/10.3390/biomedicines9121950
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author Berkowitz, Shani
Chapman, Joab
Dori, Amir
Gofrit, Shany Guly
Maggio, Nicola
Shavit-Stein, Efrat
author_facet Berkowitz, Shani
Chapman, Joab
Dori, Amir
Gofrit, Shany Guly
Maggio, Nicola
Shavit-Stein, Efrat
author_sort Berkowitz, Shani
collection PubMed
description Complement and coagulation are both key systems that defend the body from harm. They share multiple features and are similarly activated. They each play individual roles in the systemic circulation in physiology and pathophysiology, with significant crosstalk between them. Components from both systems are mapped to important structures in the central nervous system (CNS) and peripheral nervous system (PNS). Complement and coagulation participate in critical functions in neuronal development and synaptic plasticity. During pathophysiological states, complement and coagulation factors are upregulated and can modulate synaptic transmission and neuronal conduction. This review summarizes the current evidence regarding the roles of the complement system and the coagulation cascade in the CNS and PNS. Possible crosstalk between the two systems regarding neuroinflammatory-related effects on synaptic transmission and neuronal conduction is explored. Novel treatment based on the modulation of crosstalk between complement and coagulation may perhaps help to alleviate neuroinflammatory effects in diseased states of the CNS and PNS.
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spelling pubmed-86983642021-12-24 Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems Berkowitz, Shani Chapman, Joab Dori, Amir Gofrit, Shany Guly Maggio, Nicola Shavit-Stein, Efrat Biomedicines Review Complement and coagulation are both key systems that defend the body from harm. They share multiple features and are similarly activated. They each play individual roles in the systemic circulation in physiology and pathophysiology, with significant crosstalk between them. Components from both systems are mapped to important structures in the central nervous system (CNS) and peripheral nervous system (PNS). Complement and coagulation participate in critical functions in neuronal development and synaptic plasticity. During pathophysiological states, complement and coagulation factors are upregulated and can modulate synaptic transmission and neuronal conduction. This review summarizes the current evidence regarding the roles of the complement system and the coagulation cascade in the CNS and PNS. Possible crosstalk between the two systems regarding neuroinflammatory-related effects on synaptic transmission and neuronal conduction is explored. Novel treatment based on the modulation of crosstalk between complement and coagulation may perhaps help to alleviate neuroinflammatory effects in diseased states of the CNS and PNS. MDPI 2021-12-20 /pmc/articles/PMC8698364/ /pubmed/34944766 http://dx.doi.org/10.3390/biomedicines9121950 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Berkowitz, Shani
Chapman, Joab
Dori, Amir
Gofrit, Shany Guly
Maggio, Nicola
Shavit-Stein, Efrat
Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems
title Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems
title_full Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems
title_fullStr Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems
title_full_unstemmed Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems
title_short Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems
title_sort complement and coagulation system crosstalk in synaptic and neural conduction in the central and peripheral nervous systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698364/
https://www.ncbi.nlm.nih.gov/pubmed/34944766
http://dx.doi.org/10.3390/biomedicines9121950
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