Fe-mediated synthesis of N-aryl amides from nitroarenes and acyl chlorides

Amides are prevalent in nature and valuable functional compounds in agrochemical, pharmaceutical, and materials industries. In this work, we developed a selective and mild method for the synthesis of N-aryl amides. Starting from commercially available nitroarenes and acyl halides, N-aryl amides with...

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Detalles Bibliográficos
Autores principales: Wu, Yundong, Guo, Lei, Liu, Yuxuan, Xiang, Jiannan, Jiang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698440/
https://www.ncbi.nlm.nih.gov/pubmed/35424062
http://dx.doi.org/10.1039/d0ra10868e
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author Wu, Yundong
Guo, Lei
Liu, Yuxuan
Xiang, Jiannan
Jiang, Jun
author_facet Wu, Yundong
Guo, Lei
Liu, Yuxuan
Xiang, Jiannan
Jiang, Jun
author_sort Wu, Yundong
collection PubMed
description Amides are prevalent in nature and valuable functional compounds in agrochemical, pharmaceutical, and materials industries. In this work, we developed a selective and mild method for the synthesis of N-aryl amides. Starting from commercially available nitroarenes and acyl halides, N-aryl amides with good yields can be obtained in water. Especially in the process of transformation, Fe dust is the only reductant and additive, and the reaction can be easily performed on a large scale.
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spelling pubmed-86984402022-04-13 Fe-mediated synthesis of N-aryl amides from nitroarenes and acyl chlorides Wu, Yundong Guo, Lei Liu, Yuxuan Xiang, Jiannan Jiang, Jun RSC Adv Chemistry Amides are prevalent in nature and valuable functional compounds in agrochemical, pharmaceutical, and materials industries. In this work, we developed a selective and mild method for the synthesis of N-aryl amides. Starting from commercially available nitroarenes and acyl halides, N-aryl amides with good yields can be obtained in water. Especially in the process of transformation, Fe dust is the only reductant and additive, and the reaction can be easily performed on a large scale. The Royal Society of Chemistry 2021-04-23 /pmc/articles/PMC8698440/ /pubmed/35424062 http://dx.doi.org/10.1039/d0ra10868e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wu, Yundong
Guo, Lei
Liu, Yuxuan
Xiang, Jiannan
Jiang, Jun
Fe-mediated synthesis of N-aryl amides from nitroarenes and acyl chlorides
title Fe-mediated synthesis of N-aryl amides from nitroarenes and acyl chlorides
title_full Fe-mediated synthesis of N-aryl amides from nitroarenes and acyl chlorides
title_fullStr Fe-mediated synthesis of N-aryl amides from nitroarenes and acyl chlorides
title_full_unstemmed Fe-mediated synthesis of N-aryl amides from nitroarenes and acyl chlorides
title_short Fe-mediated synthesis of N-aryl amides from nitroarenes and acyl chlorides
title_sort fe-mediated synthesis of n-aryl amides from nitroarenes and acyl chlorides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698440/
https://www.ncbi.nlm.nih.gov/pubmed/35424062
http://dx.doi.org/10.1039/d0ra10868e
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AT xiangjiannan femediatedsynthesisofnarylamidesfromnitroarenesandacylchlorides
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