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Adherence to Antiplatelet Medications among Persistent and Non-Persistent Older Patients with Peripheral Arterial Disease

Secondary prevention of peripheral arterial disease (PAD) includes administration of antiplatelet agents, and adherence to medication is a requirement for an effective treatment. The aim of this study was to analyse adherence measured using the proportion of days covered (PDC) index separately in pe...

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Autores principales: Wawruch, Martin, Murin, Jan, Tesar, Tomas, Paduchova, Martina, Petrova, Miriam, Celovska, Denisa, Matalova, Petra, Havelkova, Beata, Trnka, Michal, Aarnio, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698509/
https://www.ncbi.nlm.nih.gov/pubmed/34944616
http://dx.doi.org/10.3390/biomedicines9121800
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author Wawruch, Martin
Murin, Jan
Tesar, Tomas
Paduchova, Martina
Petrova, Miriam
Celovska, Denisa
Matalova, Petra
Havelkova, Beata
Trnka, Michal
Aarnio, Emma
author_facet Wawruch, Martin
Murin, Jan
Tesar, Tomas
Paduchova, Martina
Petrova, Miriam
Celovska, Denisa
Matalova, Petra
Havelkova, Beata
Trnka, Michal
Aarnio, Emma
author_sort Wawruch, Martin
collection PubMed
description Secondary prevention of peripheral arterial disease (PAD) includes administration of antiplatelet agents, and adherence to medication is a requirement for an effective treatment. The aim of this study was to analyse adherence measured using the proportion of days covered (PDC) index separately in persistent and non-persistent patients, and to identify patient- and medication-related characteristics associated with non-adherence in these patient groups. The study cohort of 9178 patients aged ≥ 65 years in whom PAD was diagnosed in 1/–12/2012 included 6146 persistent and 3032 non-persistent patients. Non-adherence was identified as PDC < 80%. Characteristics associated with non-adherence were determined using the binary logistic regression model. In the group of persistent patients, 15.3% of subjects were identified as non-adherent, while among non-persistent patients, 26.9% of subjects were non-adherent to antiplatelet medication. Administration of dual antiplatelet therapy (aspirin and clopidogrel) and a general practitioner as index prescriber were associated with adherence in both patient groups. Our study revealed a relatively high proportion of adherent patients not only in the group of persistent patients but also in the group of non-persistent patients before discontinuation. These results indicate that most non-persistent PAD patients discontinue antiplatelet treatment rapidly after a certain period of adherence.
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spelling pubmed-86985092021-12-24 Adherence to Antiplatelet Medications among Persistent and Non-Persistent Older Patients with Peripheral Arterial Disease Wawruch, Martin Murin, Jan Tesar, Tomas Paduchova, Martina Petrova, Miriam Celovska, Denisa Matalova, Petra Havelkova, Beata Trnka, Michal Aarnio, Emma Biomedicines Article Secondary prevention of peripheral arterial disease (PAD) includes administration of antiplatelet agents, and adherence to medication is a requirement for an effective treatment. The aim of this study was to analyse adherence measured using the proportion of days covered (PDC) index separately in persistent and non-persistent patients, and to identify patient- and medication-related characteristics associated with non-adherence in these patient groups. The study cohort of 9178 patients aged ≥ 65 years in whom PAD was diagnosed in 1/–12/2012 included 6146 persistent and 3032 non-persistent patients. Non-adherence was identified as PDC < 80%. Characteristics associated with non-adherence were determined using the binary logistic regression model. In the group of persistent patients, 15.3% of subjects were identified as non-adherent, while among non-persistent patients, 26.9% of subjects were non-adherent to antiplatelet medication. Administration of dual antiplatelet therapy (aspirin and clopidogrel) and a general practitioner as index prescriber were associated with adherence in both patient groups. Our study revealed a relatively high proportion of adherent patients not only in the group of persistent patients but also in the group of non-persistent patients before discontinuation. These results indicate that most non-persistent PAD patients discontinue antiplatelet treatment rapidly after a certain period of adherence. MDPI 2021-11-30 /pmc/articles/PMC8698509/ /pubmed/34944616 http://dx.doi.org/10.3390/biomedicines9121800 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wawruch, Martin
Murin, Jan
Tesar, Tomas
Paduchova, Martina
Petrova, Miriam
Celovska, Denisa
Matalova, Petra
Havelkova, Beata
Trnka, Michal
Aarnio, Emma
Adherence to Antiplatelet Medications among Persistent and Non-Persistent Older Patients with Peripheral Arterial Disease
title Adherence to Antiplatelet Medications among Persistent and Non-Persistent Older Patients with Peripheral Arterial Disease
title_full Adherence to Antiplatelet Medications among Persistent and Non-Persistent Older Patients with Peripheral Arterial Disease
title_fullStr Adherence to Antiplatelet Medications among Persistent and Non-Persistent Older Patients with Peripheral Arterial Disease
title_full_unstemmed Adherence to Antiplatelet Medications among Persistent and Non-Persistent Older Patients with Peripheral Arterial Disease
title_short Adherence to Antiplatelet Medications among Persistent and Non-Persistent Older Patients with Peripheral Arterial Disease
title_sort adherence to antiplatelet medications among persistent and non-persistent older patients with peripheral arterial disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698509/
https://www.ncbi.nlm.nih.gov/pubmed/34944616
http://dx.doi.org/10.3390/biomedicines9121800
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