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The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis

Background: Nonalcoholic fatty liver disease is considered to be the hepatic component of metabolic syndrome (MetS). However, the association between changes in MetS status and the risk of liver cirrhosis (LC) has not been investigated to date. This study assessed the association between changes in...

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Autores principales: Chung, Goh-Eun, Chang, Young, Cho, Yuri, Cho, Eun-Ju, Yoo, Jeong-Ju, Park, Sang-Hyun, Han, Kyungdo, Shin, Dong-Wook, Yu, Su-Jong, Kim, Yoon-Jun, Yoon, Jung-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698513/
https://www.ncbi.nlm.nih.gov/pubmed/34944764
http://dx.doi.org/10.3390/biomedicines9121948
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author Chung, Goh-Eun
Chang, Young
Cho, Yuri
Cho, Eun-Ju
Yoo, Jeong-Ju
Park, Sang-Hyun
Han, Kyungdo
Shin, Dong-Wook
Yu, Su-Jong
Kim, Yoon-Jun
Yoon, Jung-Hwan
author_facet Chung, Goh-Eun
Chang, Young
Cho, Yuri
Cho, Eun-Ju
Yoo, Jeong-Ju
Park, Sang-Hyun
Han, Kyungdo
Shin, Dong-Wook
Yu, Su-Jong
Kim, Yoon-Jun
Yoon, Jung-Hwan
author_sort Chung, Goh-Eun
collection PubMed
description Background: Nonalcoholic fatty liver disease is considered to be the hepatic component of metabolic syndrome (MetS). However, the association between changes in MetS status and the risk of liver cirrhosis (LC) has not been investigated to date. This study assessed the association between changes in MetS and subsequent nonviral LC development. Methods: Data were obtained from the Korean National Health Insurance Service. Individuals who participated in health screenings from both 2009 to 2010 and 2011 to 2012 were included. The primary outcome was LC development according to the static and dynamic MetS status. Subjects were stratified into four groups according to the change in MetS status observed from the two-year interval screening (2009–2011). Cox regression analysis was used to examine the hazard ratios of LC. Results: During a median of 7.3 years of follow-up, 24,923 incident LC cases developed among 5,975,308 individuals. After adjusting for age, sex, smoking, alcohol, regular exercise, and body mass index, the adjusted hazard ratios (95% confidence intervals) for LC development were 1.39 (1.33–1.44) for the MetS-Developed group, 1.32 (1.26–1.37) for the MetS-Recovered group, and 1.51 (1.45–1.56) for the MetS-Sustained group, relative to the MetS-Free group. Stratified analyses according to age, sex, smoking, alcohol intake, exercise, diabetes mellitus, hypertension, dyslipidemia, and chronic kidney disease showed similar results. Conclusions: Both static and dynamic MetS status are independent risk factors for LC development. The risk of LC was the highest in people with sustained MetS and was lower in the MetS-Recovered group than in the MetS-Sustained group. These results suggest that improving a person’s MetS status may be helpful in preventing LC.
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spelling pubmed-86985132021-12-24 The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis Chung, Goh-Eun Chang, Young Cho, Yuri Cho, Eun-Ju Yoo, Jeong-Ju Park, Sang-Hyun Han, Kyungdo Shin, Dong-Wook Yu, Su-Jong Kim, Yoon-Jun Yoon, Jung-Hwan Biomedicines Article Background: Nonalcoholic fatty liver disease is considered to be the hepatic component of metabolic syndrome (MetS). However, the association between changes in MetS status and the risk of liver cirrhosis (LC) has not been investigated to date. This study assessed the association between changes in MetS and subsequent nonviral LC development. Methods: Data were obtained from the Korean National Health Insurance Service. Individuals who participated in health screenings from both 2009 to 2010 and 2011 to 2012 were included. The primary outcome was LC development according to the static and dynamic MetS status. Subjects were stratified into four groups according to the change in MetS status observed from the two-year interval screening (2009–2011). Cox regression analysis was used to examine the hazard ratios of LC. Results: During a median of 7.3 years of follow-up, 24,923 incident LC cases developed among 5,975,308 individuals. After adjusting for age, sex, smoking, alcohol, regular exercise, and body mass index, the adjusted hazard ratios (95% confidence intervals) for LC development were 1.39 (1.33–1.44) for the MetS-Developed group, 1.32 (1.26–1.37) for the MetS-Recovered group, and 1.51 (1.45–1.56) for the MetS-Sustained group, relative to the MetS-Free group. Stratified analyses according to age, sex, smoking, alcohol intake, exercise, diabetes mellitus, hypertension, dyslipidemia, and chronic kidney disease showed similar results. Conclusions: Both static and dynamic MetS status are independent risk factors for LC development. The risk of LC was the highest in people with sustained MetS and was lower in the MetS-Recovered group than in the MetS-Sustained group. These results suggest that improving a person’s MetS status may be helpful in preventing LC. MDPI 2021-12-20 /pmc/articles/PMC8698513/ /pubmed/34944764 http://dx.doi.org/10.3390/biomedicines9121948 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chung, Goh-Eun
Chang, Young
Cho, Yuri
Cho, Eun-Ju
Yoo, Jeong-Ju
Park, Sang-Hyun
Han, Kyungdo
Shin, Dong-Wook
Yu, Su-Jong
Kim, Yoon-Jun
Yoon, Jung-Hwan
The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis
title The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis
title_full The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis
title_fullStr The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis
title_full_unstemmed The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis
title_short The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis
title_sort change in metabolic syndrome status and the risk of nonviral liver cirrhosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698513/
https://www.ncbi.nlm.nih.gov/pubmed/34944764
http://dx.doi.org/10.3390/biomedicines9121948
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