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A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics

The functionality of soybeans is an important factor in the selection and utilization of excellent soybean cultivars, and isoflavones are representative functional substances in soybeans, which exhibit effects on antioxidants, estrogen activity, and cancer, and prevent cardiovascular diseases. This...

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Autores principales: Chu, Han-Na, Lee, Su-Ji, Wang, Xiaohan, Lee, Sang-Hoon, Yoon, Hye-Myeong, Hwang, Yu-Jin, Jung, Eun-Suk, Kwon, Yongseok, Wee, Chi-Do, Jang, Kyeong-A, Kim, Haeng-Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698514/
https://www.ncbi.nlm.nih.gov/pubmed/34943130
http://dx.doi.org/10.3390/antiox10122027
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author Chu, Han-Na
Lee, Su-Ji
Wang, Xiaohan
Lee, Sang-Hoon
Yoon, Hye-Myeong
Hwang, Yu-Jin
Jung, Eun-Suk
Kwon, Yongseok
Wee, Chi-Do
Jang, Kyeong-A
Kim, Haeng-Ran
author_facet Chu, Han-Na
Lee, Su-Ji
Wang, Xiaohan
Lee, Sang-Hoon
Yoon, Hye-Myeong
Hwang, Yu-Jin
Jung, Eun-Suk
Kwon, Yongseok
Wee, Chi-Do
Jang, Kyeong-A
Kim, Haeng-Ran
author_sort Chu, Han-Na
collection PubMed
description The functionality of soybeans is an important factor in the selection and utilization of excellent soybean cultivars, and isoflavones are representative functional substances in soybeans, which exhibit effects on antioxidants, estrogen activity, and cancer, and prevent cardiovascular diseases. This study analyzed ABTS, DPPH, estrogen, ER (ER) alpha, UCP-1, and NO inhibition activities in 48 types of soybean cultivars, as well as the relationship with 19 isolated types of individual isoflavone derivatives. Statistical analysis was conducted to find individual isoflavone derivatives affecting physiological activities, revealing the high correlation of three types of derivatives: genistein 7-O-(6″-O-acetyl)glucoside (6″-O-acetylgenistin), genistein 7-O-(2″-O-apiosyl)glucoside, and glycitein. Based on these results, 15 types of soybean cultivars were selected (one control type, seven yellow types, six black types, and one green type), which have both high physiological activities and a high content of individual isoflavone derivatives. In addition, these high correlations were further verified through a genome-wide association study (GWAS) to determine the association between activities, substances, and genetic characteristics. This study comprehensively describes the relationship between the specific physiological activities of soybean resources, individual isoflavone derivative substances, and SNPs, which will be utilized for in-depth research, such as selection of excellent soybean resources with specific physiological activities.
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spelling pubmed-86985142021-12-24 A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics Chu, Han-Na Lee, Su-Ji Wang, Xiaohan Lee, Sang-Hoon Yoon, Hye-Myeong Hwang, Yu-Jin Jung, Eun-Suk Kwon, Yongseok Wee, Chi-Do Jang, Kyeong-A Kim, Haeng-Ran Antioxidants (Basel) Article The functionality of soybeans is an important factor in the selection and utilization of excellent soybean cultivars, and isoflavones are representative functional substances in soybeans, which exhibit effects on antioxidants, estrogen activity, and cancer, and prevent cardiovascular diseases. This study analyzed ABTS, DPPH, estrogen, ER (ER) alpha, UCP-1, and NO inhibition activities in 48 types of soybean cultivars, as well as the relationship with 19 isolated types of individual isoflavone derivatives. Statistical analysis was conducted to find individual isoflavone derivatives affecting physiological activities, revealing the high correlation of three types of derivatives: genistein 7-O-(6″-O-acetyl)glucoside (6″-O-acetylgenistin), genistein 7-O-(2″-O-apiosyl)glucoside, and glycitein. Based on these results, 15 types of soybean cultivars were selected (one control type, seven yellow types, six black types, and one green type), which have both high physiological activities and a high content of individual isoflavone derivatives. In addition, these high correlations were further verified through a genome-wide association study (GWAS) to determine the association between activities, substances, and genetic characteristics. This study comprehensively describes the relationship between the specific physiological activities of soybean resources, individual isoflavone derivative substances, and SNPs, which will be utilized for in-depth research, such as selection of excellent soybean resources with specific physiological activities. MDPI 2021-12-20 /pmc/articles/PMC8698514/ /pubmed/34943130 http://dx.doi.org/10.3390/antiox10122027 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chu, Han-Na
Lee, Su-Ji
Wang, Xiaohan
Lee, Sang-Hoon
Yoon, Hye-Myeong
Hwang, Yu-Jin
Jung, Eun-Suk
Kwon, Yongseok
Wee, Chi-Do
Jang, Kyeong-A
Kim, Haeng-Ran
A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics
title A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics
title_full A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics
title_fullStr A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics
title_full_unstemmed A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics
title_short A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics
title_sort correlation study on in vitro physiological activities of soybean cultivars, 19 individual isoflavone derivatives, and genetic characteristics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698514/
https://www.ncbi.nlm.nih.gov/pubmed/34943130
http://dx.doi.org/10.3390/antiox10122027
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