Cargando…
A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics
The functionality of soybeans is an important factor in the selection and utilization of excellent soybean cultivars, and isoflavones are representative functional substances in soybeans, which exhibit effects on antioxidants, estrogen activity, and cancer, and prevent cardiovascular diseases. This...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698514/ https://www.ncbi.nlm.nih.gov/pubmed/34943130 http://dx.doi.org/10.3390/antiox10122027 |
_version_ | 1784620296549957632 |
---|---|
author | Chu, Han-Na Lee, Su-Ji Wang, Xiaohan Lee, Sang-Hoon Yoon, Hye-Myeong Hwang, Yu-Jin Jung, Eun-Suk Kwon, Yongseok Wee, Chi-Do Jang, Kyeong-A Kim, Haeng-Ran |
author_facet | Chu, Han-Na Lee, Su-Ji Wang, Xiaohan Lee, Sang-Hoon Yoon, Hye-Myeong Hwang, Yu-Jin Jung, Eun-Suk Kwon, Yongseok Wee, Chi-Do Jang, Kyeong-A Kim, Haeng-Ran |
author_sort | Chu, Han-Na |
collection | PubMed |
description | The functionality of soybeans is an important factor in the selection and utilization of excellent soybean cultivars, and isoflavones are representative functional substances in soybeans, which exhibit effects on antioxidants, estrogen activity, and cancer, and prevent cardiovascular diseases. This study analyzed ABTS, DPPH, estrogen, ER (ER) alpha, UCP-1, and NO inhibition activities in 48 types of soybean cultivars, as well as the relationship with 19 isolated types of individual isoflavone derivatives. Statistical analysis was conducted to find individual isoflavone derivatives affecting physiological activities, revealing the high correlation of three types of derivatives: genistein 7-O-(6″-O-acetyl)glucoside (6″-O-acetylgenistin), genistein 7-O-(2″-O-apiosyl)glucoside, and glycitein. Based on these results, 15 types of soybean cultivars were selected (one control type, seven yellow types, six black types, and one green type), which have both high physiological activities and a high content of individual isoflavone derivatives. In addition, these high correlations were further verified through a genome-wide association study (GWAS) to determine the association between activities, substances, and genetic characteristics. This study comprehensively describes the relationship between the specific physiological activities of soybean resources, individual isoflavone derivative substances, and SNPs, which will be utilized for in-depth research, such as selection of excellent soybean resources with specific physiological activities. |
format | Online Article Text |
id | pubmed-8698514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86985142021-12-24 A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics Chu, Han-Na Lee, Su-Ji Wang, Xiaohan Lee, Sang-Hoon Yoon, Hye-Myeong Hwang, Yu-Jin Jung, Eun-Suk Kwon, Yongseok Wee, Chi-Do Jang, Kyeong-A Kim, Haeng-Ran Antioxidants (Basel) Article The functionality of soybeans is an important factor in the selection and utilization of excellent soybean cultivars, and isoflavones are representative functional substances in soybeans, which exhibit effects on antioxidants, estrogen activity, and cancer, and prevent cardiovascular diseases. This study analyzed ABTS, DPPH, estrogen, ER (ER) alpha, UCP-1, and NO inhibition activities in 48 types of soybean cultivars, as well as the relationship with 19 isolated types of individual isoflavone derivatives. Statistical analysis was conducted to find individual isoflavone derivatives affecting physiological activities, revealing the high correlation of three types of derivatives: genistein 7-O-(6″-O-acetyl)glucoside (6″-O-acetylgenistin), genistein 7-O-(2″-O-apiosyl)glucoside, and glycitein. Based on these results, 15 types of soybean cultivars were selected (one control type, seven yellow types, six black types, and one green type), which have both high physiological activities and a high content of individual isoflavone derivatives. In addition, these high correlations were further verified through a genome-wide association study (GWAS) to determine the association between activities, substances, and genetic characteristics. This study comprehensively describes the relationship between the specific physiological activities of soybean resources, individual isoflavone derivative substances, and SNPs, which will be utilized for in-depth research, such as selection of excellent soybean resources with specific physiological activities. MDPI 2021-12-20 /pmc/articles/PMC8698514/ /pubmed/34943130 http://dx.doi.org/10.3390/antiox10122027 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chu, Han-Na Lee, Su-Ji Wang, Xiaohan Lee, Sang-Hoon Yoon, Hye-Myeong Hwang, Yu-Jin Jung, Eun-Suk Kwon, Yongseok Wee, Chi-Do Jang, Kyeong-A Kim, Haeng-Ran A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics |
title | A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics |
title_full | A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics |
title_fullStr | A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics |
title_full_unstemmed | A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics |
title_short | A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics |
title_sort | correlation study on in vitro physiological activities of soybean cultivars, 19 individual isoflavone derivatives, and genetic characteristics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698514/ https://www.ncbi.nlm.nih.gov/pubmed/34943130 http://dx.doi.org/10.3390/antiox10122027 |
work_keys_str_mv | AT chuhanna acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT leesuji acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT wangxiaohan acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT leesanghoon acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT yoonhyemyeong acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT hwangyujin acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT jungeunsuk acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT kwonyongseok acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT weechido acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT jangkyeonga acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT kimhaengran acorrelationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT chuhanna correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT leesuji correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT wangxiaohan correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT leesanghoon correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT yoonhyemyeong correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT hwangyujin correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT jungeunsuk correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT kwonyongseok correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT weechido correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT jangkyeonga correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics AT kimhaengran correlationstudyoninvitrophysiologicalactivitiesofsoybeancultivars19individualisoflavonederivativesandgeneticcharacteristics |