Cargando…
The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium
Periodontitis and diabetes mellitus (DM) are two of the most common and challenging health problems worldwide and they affect each other mutually and adversely. Current periodontal therapies have unpredictable outcome in diabetic patients. Periodontal tissue engineering is a challenging but promisin...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698546/ https://www.ncbi.nlm.nih.gov/pubmed/34940355 http://dx.doi.org/10.3390/bioengineering8120202 |
_version_ | 1784620303256649728 |
---|---|
author | Hussein, Nancy M. S. Meade, Josie L. Pandit, Hemant Jones, Elena El-Gendy, Reem |
author_facet | Hussein, Nancy M. S. Meade, Josie L. Pandit, Hemant Jones, Elena El-Gendy, Reem |
author_sort | Hussein, Nancy M. S. |
collection | PubMed |
description | Periodontitis and diabetes mellitus (DM) are two of the most common and challenging health problems worldwide and they affect each other mutually and adversely. Current periodontal therapies have unpredictable outcome in diabetic patients. Periodontal tissue engineering is a challenging but promising approach that aims at restoring periodontal tissues using one or all of the following: stem cells, signalling molecules and scaffolds. Mesenchymal stem cells (MSCs) and insulin-like growth factor (IGF) represent ideal examples of stem cells and signalling molecules. This review outlines the most recent updates in characterizing MSCs isolated from diabetics to fully understand why diabetics are more prone to periodontitis that theoretically reflect the impaired regenerative capabilities of their native stem cells. This characterisation is of utmost importance to enhance autologous stem cells based tissue regeneration in diabetic patients using both MSCs and members of IGF axis. |
format | Online Article Text |
id | pubmed-8698546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86985462021-12-24 The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium Hussein, Nancy M. S. Meade, Josie L. Pandit, Hemant Jones, Elena El-Gendy, Reem Bioengineering (Basel) Review Periodontitis and diabetes mellitus (DM) are two of the most common and challenging health problems worldwide and they affect each other mutually and adversely. Current periodontal therapies have unpredictable outcome in diabetic patients. Periodontal tissue engineering is a challenging but promising approach that aims at restoring periodontal tissues using one or all of the following: stem cells, signalling molecules and scaffolds. Mesenchymal stem cells (MSCs) and insulin-like growth factor (IGF) represent ideal examples of stem cells and signalling molecules. This review outlines the most recent updates in characterizing MSCs isolated from diabetics to fully understand why diabetics are more prone to periodontitis that theoretically reflect the impaired regenerative capabilities of their native stem cells. This characterisation is of utmost importance to enhance autologous stem cells based tissue regeneration in diabetic patients using both MSCs and members of IGF axis. MDPI 2021-12-03 /pmc/articles/PMC8698546/ /pubmed/34940355 http://dx.doi.org/10.3390/bioengineering8120202 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hussein, Nancy M. S. Meade, Josie L. Pandit, Hemant Jones, Elena El-Gendy, Reem The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium |
title | The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium |
title_full | The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium |
title_fullStr | The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium |
title_full_unstemmed | The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium |
title_short | The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium |
title_sort | effect of diabetes mellitus on igf axis and stem cell mediated regeneration of the periodontium |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698546/ https://www.ncbi.nlm.nih.gov/pubmed/34940355 http://dx.doi.org/10.3390/bioengineering8120202 |
work_keys_str_mv | AT husseinnancyms theeffectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium AT meadejosiel theeffectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium AT pandithemant theeffectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium AT joneselena theeffectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium AT elgendyreem theeffectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium AT husseinnancyms effectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium AT meadejosiel effectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium AT pandithemant effectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium AT joneselena effectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium AT elgendyreem effectofdiabetesmellitusonigfaxisandstemcellmediatedregenerationoftheperiodontium |