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The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium

Periodontitis and diabetes mellitus (DM) are two of the most common and challenging health problems worldwide and they affect each other mutually and adversely. Current periodontal therapies have unpredictable outcome in diabetic patients. Periodontal tissue engineering is a challenging but promisin...

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Autores principales: Hussein, Nancy M. S., Meade, Josie L., Pandit, Hemant, Jones, Elena, El-Gendy, Reem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698546/
https://www.ncbi.nlm.nih.gov/pubmed/34940355
http://dx.doi.org/10.3390/bioengineering8120202
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author Hussein, Nancy M. S.
Meade, Josie L.
Pandit, Hemant
Jones, Elena
El-Gendy, Reem
author_facet Hussein, Nancy M. S.
Meade, Josie L.
Pandit, Hemant
Jones, Elena
El-Gendy, Reem
author_sort Hussein, Nancy M. S.
collection PubMed
description Periodontitis and diabetes mellitus (DM) are two of the most common and challenging health problems worldwide and they affect each other mutually and adversely. Current periodontal therapies have unpredictable outcome in diabetic patients. Periodontal tissue engineering is a challenging but promising approach that aims at restoring periodontal tissues using one or all of the following: stem cells, signalling molecules and scaffolds. Mesenchymal stem cells (MSCs) and insulin-like growth factor (IGF) represent ideal examples of stem cells and signalling molecules. This review outlines the most recent updates in characterizing MSCs isolated from diabetics to fully understand why diabetics are more prone to periodontitis that theoretically reflect the impaired regenerative capabilities of their native stem cells. This characterisation is of utmost importance to enhance autologous stem cells based tissue regeneration in diabetic patients using both MSCs and members of IGF axis.
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spelling pubmed-86985462021-12-24 The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium Hussein, Nancy M. S. Meade, Josie L. Pandit, Hemant Jones, Elena El-Gendy, Reem Bioengineering (Basel) Review Periodontitis and diabetes mellitus (DM) are two of the most common and challenging health problems worldwide and they affect each other mutually and adversely. Current periodontal therapies have unpredictable outcome in diabetic patients. Periodontal tissue engineering is a challenging but promising approach that aims at restoring periodontal tissues using one or all of the following: stem cells, signalling molecules and scaffolds. Mesenchymal stem cells (MSCs) and insulin-like growth factor (IGF) represent ideal examples of stem cells and signalling molecules. This review outlines the most recent updates in characterizing MSCs isolated from diabetics to fully understand why diabetics are more prone to periodontitis that theoretically reflect the impaired regenerative capabilities of their native stem cells. This characterisation is of utmost importance to enhance autologous stem cells based tissue regeneration in diabetic patients using both MSCs and members of IGF axis. MDPI 2021-12-03 /pmc/articles/PMC8698546/ /pubmed/34940355 http://dx.doi.org/10.3390/bioengineering8120202 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hussein, Nancy M. S.
Meade, Josie L.
Pandit, Hemant
Jones, Elena
El-Gendy, Reem
The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium
title The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium
title_full The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium
title_fullStr The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium
title_full_unstemmed The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium
title_short The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium
title_sort effect of diabetes mellitus on igf axis and stem cell mediated regeneration of the periodontium
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698546/
https://www.ncbi.nlm.nih.gov/pubmed/34940355
http://dx.doi.org/10.3390/bioengineering8120202
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