Cargando…

Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands

Silver nanoparticles (AgNPs) are extensively used in many industries due to their superior antimicrobial properties. However, it is evident from many studies that AgNPs has cytotoxic potential through its effect on excessive formation of reactive oxygen species (ROS). The aim of this study was to ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Bakr, Mahmoud M., Al-Ankily, Mahmoud M., Shogaa, Sara M., Shamel, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698723/
https://www.ncbi.nlm.nih.gov/pubmed/34940372
http://dx.doi.org/10.3390/bioengineering8120219
_version_ 1784620345022480384
author Bakr, Mahmoud M.
Al-Ankily, Mahmoud M.
Shogaa, Sara M.
Shamel, Mohamed
author_facet Bakr, Mahmoud M.
Al-Ankily, Mahmoud M.
Shogaa, Sara M.
Shamel, Mohamed
author_sort Bakr, Mahmoud M.
collection PubMed
description Silver nanoparticles (AgNPs) are extensively used in many industries due to their superior antimicrobial properties. However, it is evident from many studies that AgNPs has cytotoxic potential through its effect on excessive formation of reactive oxygen species (ROS). The aim of this study was to examine the toxic effect of AgNPs on the submandibular salivary glands and the attenuating effect of vitamin E, as a natural antioxidant, against this toxicity. Thirty Albino rats were divided into 3 groups (n = 10): control group, AgNPs group receiving 2 mg/kg daily for 28 days, and AgNPs and vitamin E group receiving AgNPs the same as the previous group in addition to vitamin E at a dose of 100 mg/kg. Microscopic, ultrastructural, and cytokeratin immune-reactivity examination of the glands were performed. The AgNPs group showed noticeable degeneration in all structures of the gland as evident in the histological and ultrastructural examination. The AgNPs and vitamin E group revealed an improvement of the glandular elements. A significant increase in cytokeratin immune expression was found after comparison of both groups (p = 0.01). This current study shows that vitamin E has powerful antioxidant properties, which can combat the cytotoxic effect caused by AgNPs. Further studies are deemed necessary to confirm this finding using other immunohistochemical markers, such as myosin and E-cadherin.
format Online
Article
Text
id pubmed-8698723
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86987232021-12-24 Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands Bakr, Mahmoud M. Al-Ankily, Mahmoud M. Shogaa, Sara M. Shamel, Mohamed Bioengineering (Basel) Article Silver nanoparticles (AgNPs) are extensively used in many industries due to their superior antimicrobial properties. However, it is evident from many studies that AgNPs has cytotoxic potential through its effect on excessive formation of reactive oxygen species (ROS). The aim of this study was to examine the toxic effect of AgNPs on the submandibular salivary glands and the attenuating effect of vitamin E, as a natural antioxidant, against this toxicity. Thirty Albino rats were divided into 3 groups (n = 10): control group, AgNPs group receiving 2 mg/kg daily for 28 days, and AgNPs and vitamin E group receiving AgNPs the same as the previous group in addition to vitamin E at a dose of 100 mg/kg. Microscopic, ultrastructural, and cytokeratin immune-reactivity examination of the glands were performed. The AgNPs group showed noticeable degeneration in all structures of the gland as evident in the histological and ultrastructural examination. The AgNPs and vitamin E group revealed an improvement of the glandular elements. A significant increase in cytokeratin immune expression was found after comparison of both groups (p = 0.01). This current study shows that vitamin E has powerful antioxidant properties, which can combat the cytotoxic effect caused by AgNPs. Further studies are deemed necessary to confirm this finding using other immunohistochemical markers, such as myosin and E-cadherin. MDPI 2021-12-16 /pmc/articles/PMC8698723/ /pubmed/34940372 http://dx.doi.org/10.3390/bioengineering8120219 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bakr, Mahmoud M.
Al-Ankily, Mahmoud M.
Shogaa, Sara M.
Shamel, Mohamed
Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands
title Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands
title_full Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands
title_fullStr Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands
title_full_unstemmed Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands
title_short Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands
title_sort attenuating effect of vitamin e against silver nano particles toxicity in submandibular salivary glands
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698723/
https://www.ncbi.nlm.nih.gov/pubmed/34940372
http://dx.doi.org/10.3390/bioengineering8120219
work_keys_str_mv AT bakrmahmoudm attenuatingeffectofvitamineagainstsilvernanoparticlestoxicityinsubmandibularsalivaryglands
AT alankilymahmoudm attenuatingeffectofvitamineagainstsilvernanoparticlestoxicityinsubmandibularsalivaryglands
AT shogaasaram attenuatingeffectofvitamineagainstsilvernanoparticlestoxicityinsubmandibularsalivaryglands
AT shamelmohamed attenuatingeffectofvitamineagainstsilvernanoparticlestoxicityinsubmandibularsalivaryglands