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Potential Solutions Using Bacteriophages against Antimicrobial Resistant Bacteria

Bacteriophages are viruses that specifically infect a bacterial host. They play a great role in the modern biotechnology and antibiotic-resistant microbe era. Since the discovery of phages, their application as a control agent has faced challenges that made antibiotics a better fit for combating pat...

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Detalles Bibliográficos
Autores principales: Rahimi-Midani, Aryan, Lee, Seon-Woo, Choi, Tae-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698741/
https://www.ncbi.nlm.nih.gov/pubmed/34943708
http://dx.doi.org/10.3390/antibiotics10121496
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author Rahimi-Midani, Aryan
Lee, Seon-Woo
Choi, Tae-Jin
author_facet Rahimi-Midani, Aryan
Lee, Seon-Woo
Choi, Tae-Jin
author_sort Rahimi-Midani, Aryan
collection PubMed
description Bacteriophages are viruses that specifically infect a bacterial host. They play a great role in the modern biotechnology and antibiotic-resistant microbe era. Since the discovery of phages, their application as a control agent has faced challenges that made antibiotics a better fit for combating pathogenic bacteria. Recently, with the novel sequencing technologies providing new insight into the nature of bacteriophages, their application has a second chance to be used. However, novel challenges need to be addressed to provide proper strategies for their practical application. This review focuses on addressing these challenges by initially introducing the nature of bacteriophages and describing the phage-host-dependent strategies for phage application. We also describe the effect of the long-term application of phages in natural environments and other bacterial communities. Overall, this review gathered crucial information for the future application of phages. We predict the use of phages will not be the only control strategy against pathogenic bacteria. Therefore, more studies must be done for low-risk control methods against antimicrobial-resistant bacteria.
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spelling pubmed-86987412021-12-24 Potential Solutions Using Bacteriophages against Antimicrobial Resistant Bacteria Rahimi-Midani, Aryan Lee, Seon-Woo Choi, Tae-Jin Antibiotics (Basel) Review Bacteriophages are viruses that specifically infect a bacterial host. They play a great role in the modern biotechnology and antibiotic-resistant microbe era. Since the discovery of phages, their application as a control agent has faced challenges that made antibiotics a better fit for combating pathogenic bacteria. Recently, with the novel sequencing technologies providing new insight into the nature of bacteriophages, their application has a second chance to be used. However, novel challenges need to be addressed to provide proper strategies for their practical application. This review focuses on addressing these challenges by initially introducing the nature of bacteriophages and describing the phage-host-dependent strategies for phage application. We also describe the effect of the long-term application of phages in natural environments and other bacterial communities. Overall, this review gathered crucial information for the future application of phages. We predict the use of phages will not be the only control strategy against pathogenic bacteria. Therefore, more studies must be done for low-risk control methods against antimicrobial-resistant bacteria. MDPI 2021-12-06 /pmc/articles/PMC8698741/ /pubmed/34943708 http://dx.doi.org/10.3390/antibiotics10121496 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rahimi-Midani, Aryan
Lee, Seon-Woo
Choi, Tae-Jin
Potential Solutions Using Bacteriophages against Antimicrobial Resistant Bacteria
title Potential Solutions Using Bacteriophages against Antimicrobial Resistant Bacteria
title_full Potential Solutions Using Bacteriophages against Antimicrobial Resistant Bacteria
title_fullStr Potential Solutions Using Bacteriophages against Antimicrobial Resistant Bacteria
title_full_unstemmed Potential Solutions Using Bacteriophages against Antimicrobial Resistant Bacteria
title_short Potential Solutions Using Bacteriophages against Antimicrobial Resistant Bacteria
title_sort potential solutions using bacteriophages against antimicrobial resistant bacteria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698741/
https://www.ncbi.nlm.nih.gov/pubmed/34943708
http://dx.doi.org/10.3390/antibiotics10121496
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