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Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism

The clinical characteristics and surgical prognosis of glucocorticoid-remediable aldosteronism (GRA, also known as familial hyperaldosteronism type 1, FH-I) have not been widely studied. Using data from the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry retrospectively, we describe the...

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Autores principales: Cheng, Chung-Yi, Liao, Hung-Wei, Peng, Kang-Yung, Chen, Tso-Hsiao, Lin, Yen-Hung, Chueh, Jeff S., Wu, Vin-Cent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698750/
https://www.ncbi.nlm.nih.gov/pubmed/34944634
http://dx.doi.org/10.3390/biomedicines9121816
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author Cheng, Chung-Yi
Liao, Hung-Wei
Peng, Kang-Yung
Chen, Tso-Hsiao
Lin, Yen-Hung
Chueh, Jeff S.
Wu, Vin-Cent
author_facet Cheng, Chung-Yi
Liao, Hung-Wei
Peng, Kang-Yung
Chen, Tso-Hsiao
Lin, Yen-Hung
Chueh, Jeff S.
Wu, Vin-Cent
author_sort Cheng, Chung-Yi
collection PubMed
description The clinical characteristics and surgical prognosis of glucocorticoid-remediable aldosteronism (GRA, also known as familial hyperaldosteronism type 1, FH-I) have not been widely studied. Using data from the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry retrospectively, we describe the associated clinical factors for GRA and clinical predictors of surgical outcomes among identified GRA patients. We found 79 GRA-positive (51.2 ± 13.8 years; women 39 (49.4%)) and 114 GRA-negative primary aldosteronism (PA) patients matched with age, gender, and body mass index. Lower plasma aldosterone concentrations (PACs) and aldosterone-renin ratios were found among GRA-positive individuals. Multivariable logistic regression demonstrated that a PAC ≤ 40 ng/dL could predict concealed GRA individuals (OR 0.523, p = 0.037). Low serum potassium (OR 0.285, p = 0.008), but not the presence of GRA, was associated with hypertension-remission. Of note, PRA (OR 11.645, p = 0.045) and hypokalemia (OR 0.133, p = 0.048) were associated with hypertension-remission in GRA patients. Unilateral primary aldosteronism patients harboring concomitant GRA were not associated with inferior hypertension-remission after an adrenalectomy. Low serum potassium and high PRA were positively associated with hypertension-remission in GRA patients.
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spelling pubmed-86987502021-12-24 Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism Cheng, Chung-Yi Liao, Hung-Wei Peng, Kang-Yung Chen, Tso-Hsiao Lin, Yen-Hung Chueh, Jeff S. Wu, Vin-Cent Biomedicines Article The clinical characteristics and surgical prognosis of glucocorticoid-remediable aldosteronism (GRA, also known as familial hyperaldosteronism type 1, FH-I) have not been widely studied. Using data from the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry retrospectively, we describe the associated clinical factors for GRA and clinical predictors of surgical outcomes among identified GRA patients. We found 79 GRA-positive (51.2 ± 13.8 years; women 39 (49.4%)) and 114 GRA-negative primary aldosteronism (PA) patients matched with age, gender, and body mass index. Lower plasma aldosterone concentrations (PACs) and aldosterone-renin ratios were found among GRA-positive individuals. Multivariable logistic regression demonstrated that a PAC ≤ 40 ng/dL could predict concealed GRA individuals (OR 0.523, p = 0.037). Low serum potassium (OR 0.285, p = 0.008), but not the presence of GRA, was associated with hypertension-remission. Of note, PRA (OR 11.645, p = 0.045) and hypokalemia (OR 0.133, p = 0.048) were associated with hypertension-remission in GRA patients. Unilateral primary aldosteronism patients harboring concomitant GRA were not associated with inferior hypertension-remission after an adrenalectomy. Low serum potassium and high PRA were positively associated with hypertension-remission in GRA patients. MDPI 2021-12-02 /pmc/articles/PMC8698750/ /pubmed/34944634 http://dx.doi.org/10.3390/biomedicines9121816 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Chung-Yi
Liao, Hung-Wei
Peng, Kang-Yung
Chen, Tso-Hsiao
Lin, Yen-Hung
Chueh, Jeff S.
Wu, Vin-Cent
Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism
title Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism
title_full Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism
title_fullStr Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism
title_full_unstemmed Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism
title_short Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism
title_sort characteristics and outcomes in primary aldosteronism patients harboring glucocorticoid-remediable aldosteronism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698750/
https://www.ncbi.nlm.nih.gov/pubmed/34944634
http://dx.doi.org/10.3390/biomedicines9121816
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