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Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review

Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artif...

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Autores principales: Kuchinka, Janna, Willems, Christian, Telyshev, Dmitry V., Groth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698751/
https://www.ncbi.nlm.nih.gov/pubmed/34940368
http://dx.doi.org/10.3390/bioengineering8120215
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author Kuchinka, Janna
Willems, Christian
Telyshev, Dmitry V.
Groth, Thomas
author_facet Kuchinka, Janna
Willems, Christian
Telyshev, Dmitry V.
Groth, Thomas
author_sort Kuchinka, Janna
collection PubMed
description Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artificial kidneys (hemodialysis), extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass. Although lower blood compatibility of materials and devices can be handled with systemic anticoagulation, its side effects, such as an increased bleeding risk, make materials that have a better hemocompatibility highly desirable, particularly in long-term applications. This review provides a short overview on the basic mechanisms of blood coagulation including plasmatic coagulation and blood platelets, as well as the activation of the complement system. Furthermore, a survey on concepts for tailoring the blood response of biomaterials to improve the hemocompatibility of medical devices is given which covers different approaches that either inhibit interaction of material surfaces with blood components completely or control the response of the coagulation system, blood platelets and leukocytes.
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spelling pubmed-86987512021-12-24 Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review Kuchinka, Janna Willems, Christian Telyshev, Dmitry V. Groth, Thomas Bioengineering (Basel) Review Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artificial kidneys (hemodialysis), extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass. Although lower blood compatibility of materials and devices can be handled with systemic anticoagulation, its side effects, such as an increased bleeding risk, make materials that have a better hemocompatibility highly desirable, particularly in long-term applications. This review provides a short overview on the basic mechanisms of blood coagulation including plasmatic coagulation and blood platelets, as well as the activation of the complement system. Furthermore, a survey on concepts for tailoring the blood response of biomaterials to improve the hemocompatibility of medical devices is given which covers different approaches that either inhibit interaction of material surfaces with blood components completely or control the response of the coagulation system, blood platelets and leukocytes. MDPI 2021-12-15 /pmc/articles/PMC8698751/ /pubmed/34940368 http://dx.doi.org/10.3390/bioengineering8120215 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kuchinka, Janna
Willems, Christian
Telyshev, Dmitry V.
Groth, Thomas
Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review
title Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review
title_full Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review
title_fullStr Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review
title_full_unstemmed Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review
title_short Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review
title_sort control of blood coagulation by hemocompatible material surfaces—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698751/
https://www.ncbi.nlm.nih.gov/pubmed/34940368
http://dx.doi.org/10.3390/bioengineering8120215
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