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Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review
Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artif...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698751/ https://www.ncbi.nlm.nih.gov/pubmed/34940368 http://dx.doi.org/10.3390/bioengineering8120215 |
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author | Kuchinka, Janna Willems, Christian Telyshev, Dmitry V. Groth, Thomas |
author_facet | Kuchinka, Janna Willems, Christian Telyshev, Dmitry V. Groth, Thomas |
author_sort | Kuchinka, Janna |
collection | PubMed |
description | Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artificial kidneys (hemodialysis), extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass. Although lower blood compatibility of materials and devices can be handled with systemic anticoagulation, its side effects, such as an increased bleeding risk, make materials that have a better hemocompatibility highly desirable, particularly in long-term applications. This review provides a short overview on the basic mechanisms of blood coagulation including plasmatic coagulation and blood platelets, as well as the activation of the complement system. Furthermore, a survey on concepts for tailoring the blood response of biomaterials to improve the hemocompatibility of medical devices is given which covers different approaches that either inhibit interaction of material surfaces with blood components completely or control the response of the coagulation system, blood platelets and leukocytes. |
format | Online Article Text |
id | pubmed-8698751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86987512021-12-24 Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review Kuchinka, Janna Willems, Christian Telyshev, Dmitry V. Groth, Thomas Bioengineering (Basel) Review Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artificial kidneys (hemodialysis), extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass. Although lower blood compatibility of materials and devices can be handled with systemic anticoagulation, its side effects, such as an increased bleeding risk, make materials that have a better hemocompatibility highly desirable, particularly in long-term applications. This review provides a short overview on the basic mechanisms of blood coagulation including plasmatic coagulation and blood platelets, as well as the activation of the complement system. Furthermore, a survey on concepts for tailoring the blood response of biomaterials to improve the hemocompatibility of medical devices is given which covers different approaches that either inhibit interaction of material surfaces with blood components completely or control the response of the coagulation system, blood platelets and leukocytes. MDPI 2021-12-15 /pmc/articles/PMC8698751/ /pubmed/34940368 http://dx.doi.org/10.3390/bioengineering8120215 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kuchinka, Janna Willems, Christian Telyshev, Dmitry V. Groth, Thomas Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review |
title | Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review |
title_full | Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review |
title_fullStr | Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review |
title_full_unstemmed | Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review |
title_short | Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review |
title_sort | control of blood coagulation by hemocompatible material surfaces—a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698751/ https://www.ncbi.nlm.nih.gov/pubmed/34940368 http://dx.doi.org/10.3390/bioengineering8120215 |
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