Cargando…

Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers

Information flow from a source to a receiver becomes informative when the recipient can process the signal into a meaningful form. Information exchange and interpretation is essential in biology and understanding how cells integrate signals from a variety of information-coding molecules into complex...

Descripción completa

Detalles Bibliográficos
Autores principales: Maggio, Roberto, Fasciani, Irene, Carli, Marco, Petragnano, Francesco, Marampon, Francesco, Rossi, Mario, Scarselli, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698773/
https://www.ncbi.nlm.nih.gov/pubmed/34944469
http://dx.doi.org/10.3390/biom11121828
_version_ 1784620357391482880
author Maggio, Roberto
Fasciani, Irene
Carli, Marco
Petragnano, Francesco
Marampon, Francesco
Rossi, Mario
Scarselli, Marco
author_facet Maggio, Roberto
Fasciani, Irene
Carli, Marco
Petragnano, Francesco
Marampon, Francesco
Rossi, Mario
Scarselli, Marco
author_sort Maggio, Roberto
collection PubMed
description Information flow from a source to a receiver becomes informative when the recipient can process the signal into a meaningful form. Information exchange and interpretation is essential in biology and understanding how cells integrate signals from a variety of information-coding molecules into complex orchestrated responses is a major challenge for modern cell biology. In complex organisms, cell to cell communication occurs mostly through neurotransmitters and hormones, and receptors are responsible for signal recognition at the membrane level and information transduction inside the cell. The G protein-coupled receptors (GPCRs) are the largest family of membrane receptors, with nearly 800 genes coding for these proteins. The recognition that GPCRs may physically interact with each other has led to the hypothesis that their dimeric state can provide the framework for temporal coincidence in signaling pathways. Furthermore, the formation of GPCRs higher order oligomers provides the structural basis for organizing distinct cell compartments along the plasma membrane where confined increases in second messengers may be perceived and discriminated. Here, we summarize evidence that supports these conjectures, fostering new ideas about the physiological role played by receptor homo- and hetero-oligomerization in cell biology.
format Online
Article
Text
id pubmed-8698773
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86987732021-12-24 Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers Maggio, Roberto Fasciani, Irene Carli, Marco Petragnano, Francesco Marampon, Francesco Rossi, Mario Scarselli, Marco Biomolecules Review Information flow from a source to a receiver becomes informative when the recipient can process the signal into a meaningful form. Information exchange and interpretation is essential in biology and understanding how cells integrate signals from a variety of information-coding molecules into complex orchestrated responses is a major challenge for modern cell biology. In complex organisms, cell to cell communication occurs mostly through neurotransmitters and hormones, and receptors are responsible for signal recognition at the membrane level and information transduction inside the cell. The G protein-coupled receptors (GPCRs) are the largest family of membrane receptors, with nearly 800 genes coding for these proteins. The recognition that GPCRs may physically interact with each other has led to the hypothesis that their dimeric state can provide the framework for temporal coincidence in signaling pathways. Furthermore, the formation of GPCRs higher order oligomers provides the structural basis for organizing distinct cell compartments along the plasma membrane where confined increases in second messengers may be perceived and discriminated. Here, we summarize evidence that supports these conjectures, fostering new ideas about the physiological role played by receptor homo- and hetero-oligomerization in cell biology. MDPI 2021-12-03 /pmc/articles/PMC8698773/ /pubmed/34944469 http://dx.doi.org/10.3390/biom11121828 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maggio, Roberto
Fasciani, Irene
Carli, Marco
Petragnano, Francesco
Marampon, Francesco
Rossi, Mario
Scarselli, Marco
Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers
title Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers
title_full Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers
title_fullStr Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers
title_full_unstemmed Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers
title_short Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers
title_sort integration and spatial organization of signaling by g protein-coupled receptor homo- and heterodimers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698773/
https://www.ncbi.nlm.nih.gov/pubmed/34944469
http://dx.doi.org/10.3390/biom11121828
work_keys_str_mv AT maggioroberto integrationandspatialorganizationofsignalingbygproteincoupledreceptorhomoandheterodimers
AT fascianiirene integrationandspatialorganizationofsignalingbygproteincoupledreceptorhomoandheterodimers
AT carlimarco integrationandspatialorganizationofsignalingbygproteincoupledreceptorhomoandheterodimers
AT petragnanofrancesco integrationandspatialorganizationofsignalingbygproteincoupledreceptorhomoandheterodimers
AT maramponfrancesco integrationandspatialorganizationofsignalingbygproteincoupledreceptorhomoandheterodimers
AT rossimario integrationandspatialorganizationofsignalingbygproteincoupledreceptorhomoandheterodimers
AT scarsellimarco integrationandspatialorganizationofsignalingbygproteincoupledreceptorhomoandheterodimers