Cargando…

Bacterial Epidemiology of Surgical Site Infections after Open Fractures of the Lower Limb: A Retrospective Cohort Study

Open lower limb fractures are common injuries, and the occurrence of infectious complications after open fractures is a usual problem. The rate of surgical site infections (SSIs) and the nature and resistance of the germs responsible for SSIs remain poorly described. Our aim was to describe the bact...

Descripción completa

Detalles Bibliográficos
Autores principales: Youbong, Tracie Joyner, De Pontfarcy, Astrid, Rouyer, Maxence, Strazzula, Alessio, Chakvetadze, Catherine, Flateau, Clara, Sayegh, Samir, Noel, Coralie, Pitsch, Aurélia, Abbadi, Abdelmalek, Diamantis, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698788/
https://www.ncbi.nlm.nih.gov/pubmed/34943725
http://dx.doi.org/10.3390/antibiotics10121513
_version_ 1784620361099247616
author Youbong, Tracie Joyner
De Pontfarcy, Astrid
Rouyer, Maxence
Strazzula, Alessio
Chakvetadze, Catherine
Flateau, Clara
Sayegh, Samir
Noel, Coralie
Pitsch, Aurélia
Abbadi, Abdelmalek
Diamantis, Sylvain
author_facet Youbong, Tracie Joyner
De Pontfarcy, Astrid
Rouyer, Maxence
Strazzula, Alessio
Chakvetadze, Catherine
Flateau, Clara
Sayegh, Samir
Noel, Coralie
Pitsch, Aurélia
Abbadi, Abdelmalek
Diamantis, Sylvain
author_sort Youbong, Tracie Joyner
collection PubMed
description Open lower limb fractures are common injuries, and the occurrence of infectious complications after open fractures is a usual problem. The rate of surgical site infections (SSIs) and the nature and resistance of the germs responsible for SSIs remain poorly described. Our aim was to describe the bacterial epidemiology of SSIs after surgical management of an open lower limb fracture. We conducted a retrospective monocentric cohort study from 1 January 2012 to 31 December 2020 based on the analysis of inpatient records in a non-university hospital of Ile de France region. All patients who underwent surgery for an open lower limb fracture were included. A total of 149 patients were included. In our population, 19 (12.7%) patients developed an SSI. Of these 19 patients, the sample was polymicrobial in 9 (47.4%) patients. In 9 (45%) cases, the samples identified a group 3 enterobacteria, Enterobacter cloacae being the main one in 7 (36.9%) cases. Staphylococci were identified in 11 patients, with Staphylococcus aureus in 9 (47.4%). All Staphylococcus aureus were susceptible to methicillin, and all enterobacteria were susceptible to C3G. Among all SSI, 10 (58.8%) contained at least one germ resistant to amoxicillin/clavulanic acid (AMC). The SSIs rate was 12.7%. The main pathogens identified were Enterobacter cloacae and Staphylococcus aureus. The presence of early SSI caused by group 3 Enterobacteriaceae renders current antibiotic prophylaxis protocols inadequate with AMC in half the cases.
format Online
Article
Text
id pubmed-8698788
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86987882021-12-24 Bacterial Epidemiology of Surgical Site Infections after Open Fractures of the Lower Limb: A Retrospective Cohort Study Youbong, Tracie Joyner De Pontfarcy, Astrid Rouyer, Maxence Strazzula, Alessio Chakvetadze, Catherine Flateau, Clara Sayegh, Samir Noel, Coralie Pitsch, Aurélia Abbadi, Abdelmalek Diamantis, Sylvain Antibiotics (Basel) Article Open lower limb fractures are common injuries, and the occurrence of infectious complications after open fractures is a usual problem. The rate of surgical site infections (SSIs) and the nature and resistance of the germs responsible for SSIs remain poorly described. Our aim was to describe the bacterial epidemiology of SSIs after surgical management of an open lower limb fracture. We conducted a retrospective monocentric cohort study from 1 January 2012 to 31 December 2020 based on the analysis of inpatient records in a non-university hospital of Ile de France region. All patients who underwent surgery for an open lower limb fracture were included. A total of 149 patients were included. In our population, 19 (12.7%) patients developed an SSI. Of these 19 patients, the sample was polymicrobial in 9 (47.4%) patients. In 9 (45%) cases, the samples identified a group 3 enterobacteria, Enterobacter cloacae being the main one in 7 (36.9%) cases. Staphylococci were identified in 11 patients, with Staphylococcus aureus in 9 (47.4%). All Staphylococcus aureus were susceptible to methicillin, and all enterobacteria were susceptible to C3G. Among all SSI, 10 (58.8%) contained at least one germ resistant to amoxicillin/clavulanic acid (AMC). The SSIs rate was 12.7%. The main pathogens identified were Enterobacter cloacae and Staphylococcus aureus. The presence of early SSI caused by group 3 Enterobacteriaceae renders current antibiotic prophylaxis protocols inadequate with AMC in half the cases. MDPI 2021-12-10 /pmc/articles/PMC8698788/ /pubmed/34943725 http://dx.doi.org/10.3390/antibiotics10121513 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Youbong, Tracie Joyner
De Pontfarcy, Astrid
Rouyer, Maxence
Strazzula, Alessio
Chakvetadze, Catherine
Flateau, Clara
Sayegh, Samir
Noel, Coralie
Pitsch, Aurélia
Abbadi, Abdelmalek
Diamantis, Sylvain
Bacterial Epidemiology of Surgical Site Infections after Open Fractures of the Lower Limb: A Retrospective Cohort Study
title Bacterial Epidemiology of Surgical Site Infections after Open Fractures of the Lower Limb: A Retrospective Cohort Study
title_full Bacterial Epidemiology of Surgical Site Infections after Open Fractures of the Lower Limb: A Retrospective Cohort Study
title_fullStr Bacterial Epidemiology of Surgical Site Infections after Open Fractures of the Lower Limb: A Retrospective Cohort Study
title_full_unstemmed Bacterial Epidemiology of Surgical Site Infections after Open Fractures of the Lower Limb: A Retrospective Cohort Study
title_short Bacterial Epidemiology of Surgical Site Infections after Open Fractures of the Lower Limb: A Retrospective Cohort Study
title_sort bacterial epidemiology of surgical site infections after open fractures of the lower limb: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698788/
https://www.ncbi.nlm.nih.gov/pubmed/34943725
http://dx.doi.org/10.3390/antibiotics10121513
work_keys_str_mv AT youbongtraciejoyner bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT depontfarcyastrid bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT rouyermaxence bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT strazzulaalessio bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT chakvetadzecatherine bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT flateauclara bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT sayeghsamir bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT noelcoralie bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT pitschaurelia bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT abbadiabdelmalek bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy
AT diamantissylvain bacterialepidemiologyofsurgicalsiteinfectionsafteropenfracturesofthelowerlimbaretrospectivecohortstudy