CRISPR/dCas9 Transcriptional Activation of Endogenous Apolipoprotein AI and Paraoxonase 1 in Enterocytes Alleviates Endothelial Cell Dysfunction

Atherosclerosis is the main cause of cardiovascular diseases with high prevalence worldwide. A promising therapeutic strategy to reverse atherosclerotic process is to improve the athero-protective potential of high-density lipoproteins (HDL). Since the small intestine is a source of HDL, we aimed to...

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Detalles Bibliográficos
Autores principales: Toma, Laura, Barbălată, Teodora, Sanda, Gabriela M., Niculescu, Loredan S., Sima, Anca V., Stancu, Camelia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698862/
https://www.ncbi.nlm.nih.gov/pubmed/34944413
http://dx.doi.org/10.3390/biom11121769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698862/
https://www.ncbi.nlm.nih.gov/pubmed/34944413
http://dx.doi.org/10.3390/biom11121769

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