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Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders

Peroxisome proliferator-activated receptors (PPAR-γ, PPAR-α, and PPAR-β/δ) are ligand-dependent nuclear receptors that play a critical role in the regulation of hundreds of genes through their activation. Their expression and targeted activation play an important role in the treatment of a variety o...

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Autores principales: , Sanjay, Sharma, Anshul, Lee, Hae-Jeung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698906/
https://www.ncbi.nlm.nih.gov/pubmed/34944727
http://dx.doi.org/10.3390/biomedicines9121914
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author , Sanjay
Sharma, Anshul
Lee, Hae-Jeung
author_facet , Sanjay
Sharma, Anshul
Lee, Hae-Jeung
author_sort , Sanjay
collection PubMed
description Peroxisome proliferator-activated receptors (PPAR-γ, PPAR-α, and PPAR-β/δ) are ligand-dependent nuclear receptors that play a critical role in the regulation of hundreds of genes through their activation. Their expression and targeted activation play an important role in the treatment of a variety of diseases, including neurodegenerative, cardiovascular, diabetes, and cancer. In recent years, several reviews have been published describing the therapeutic potential of PPAR agonists (natural or synthetic) in the disorders listed above; however, no comprehensive report defining the role of naturally derived phytoconstituents as PPAR agonists targeting neurodegenerative diseases has been published. This review will focus on the role of phytoconstituents as PPAR agonists and the relevant preclinical studies and mechanistic insights into their neuroprotective effects. Exemplary research includes flavonoids, fatty acids, cannabinoids, curcumin, genistein, capsaicin, and piperine, all of which have been shown to be PPAR agonists either directly or indirectly. Additionally, a few studies have demonstrated the use of clinical samples in in vitro investigations. The role of the fruit fly Drosophila melanogaster as a potential model for studying neurodegenerative diseases has also been highlighted.
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spelling pubmed-86989062021-12-24 Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders , Sanjay Sharma, Anshul Lee, Hae-Jeung Biomedicines Review Peroxisome proliferator-activated receptors (PPAR-γ, PPAR-α, and PPAR-β/δ) are ligand-dependent nuclear receptors that play a critical role in the regulation of hundreds of genes through their activation. Their expression and targeted activation play an important role in the treatment of a variety of diseases, including neurodegenerative, cardiovascular, diabetes, and cancer. In recent years, several reviews have been published describing the therapeutic potential of PPAR agonists (natural or synthetic) in the disorders listed above; however, no comprehensive report defining the role of naturally derived phytoconstituents as PPAR agonists targeting neurodegenerative diseases has been published. This review will focus on the role of phytoconstituents as PPAR agonists and the relevant preclinical studies and mechanistic insights into their neuroprotective effects. Exemplary research includes flavonoids, fatty acids, cannabinoids, curcumin, genistein, capsaicin, and piperine, all of which have been shown to be PPAR agonists either directly or indirectly. Additionally, a few studies have demonstrated the use of clinical samples in in vitro investigations. The role of the fruit fly Drosophila melanogaster as a potential model for studying neurodegenerative diseases has also been highlighted. MDPI 2021-12-14 /pmc/articles/PMC8698906/ /pubmed/34944727 http://dx.doi.org/10.3390/biomedicines9121914 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
, Sanjay
Sharma, Anshul
Lee, Hae-Jeung
Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
title Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
title_full Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
title_fullStr Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
title_full_unstemmed Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
title_short Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
title_sort role of phytoconstituents as ppar agonists: implications for neurodegenerative disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698906/
https://www.ncbi.nlm.nih.gov/pubmed/34944727
http://dx.doi.org/10.3390/biomedicines9121914
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