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Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
Peroxisome proliferator-activated receptors (PPAR-γ, PPAR-α, and PPAR-β/δ) are ligand-dependent nuclear receptors that play a critical role in the regulation of hundreds of genes through their activation. Their expression and targeted activation play an important role in the treatment of a variety o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698906/ https://www.ncbi.nlm.nih.gov/pubmed/34944727 http://dx.doi.org/10.3390/biomedicines9121914 |
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author | , Sanjay Sharma, Anshul Lee, Hae-Jeung |
author_facet | , Sanjay Sharma, Anshul Lee, Hae-Jeung |
author_sort | , Sanjay |
collection | PubMed |
description | Peroxisome proliferator-activated receptors (PPAR-γ, PPAR-α, and PPAR-β/δ) are ligand-dependent nuclear receptors that play a critical role in the regulation of hundreds of genes through their activation. Their expression and targeted activation play an important role in the treatment of a variety of diseases, including neurodegenerative, cardiovascular, diabetes, and cancer. In recent years, several reviews have been published describing the therapeutic potential of PPAR agonists (natural or synthetic) in the disorders listed above; however, no comprehensive report defining the role of naturally derived phytoconstituents as PPAR agonists targeting neurodegenerative diseases has been published. This review will focus on the role of phytoconstituents as PPAR agonists and the relevant preclinical studies and mechanistic insights into their neuroprotective effects. Exemplary research includes flavonoids, fatty acids, cannabinoids, curcumin, genistein, capsaicin, and piperine, all of which have been shown to be PPAR agonists either directly or indirectly. Additionally, a few studies have demonstrated the use of clinical samples in in vitro investigations. The role of the fruit fly Drosophila melanogaster as a potential model for studying neurodegenerative diseases has also been highlighted. |
format | Online Article Text |
id | pubmed-8698906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86989062021-12-24 Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders , Sanjay Sharma, Anshul Lee, Hae-Jeung Biomedicines Review Peroxisome proliferator-activated receptors (PPAR-γ, PPAR-α, and PPAR-β/δ) are ligand-dependent nuclear receptors that play a critical role in the regulation of hundreds of genes through their activation. Their expression and targeted activation play an important role in the treatment of a variety of diseases, including neurodegenerative, cardiovascular, diabetes, and cancer. In recent years, several reviews have been published describing the therapeutic potential of PPAR agonists (natural or synthetic) in the disorders listed above; however, no comprehensive report defining the role of naturally derived phytoconstituents as PPAR agonists targeting neurodegenerative diseases has been published. This review will focus on the role of phytoconstituents as PPAR agonists and the relevant preclinical studies and mechanistic insights into their neuroprotective effects. Exemplary research includes flavonoids, fatty acids, cannabinoids, curcumin, genistein, capsaicin, and piperine, all of which have been shown to be PPAR agonists either directly or indirectly. Additionally, a few studies have demonstrated the use of clinical samples in in vitro investigations. The role of the fruit fly Drosophila melanogaster as a potential model for studying neurodegenerative diseases has also been highlighted. MDPI 2021-12-14 /pmc/articles/PMC8698906/ /pubmed/34944727 http://dx.doi.org/10.3390/biomedicines9121914 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review , Sanjay Sharma, Anshul Lee, Hae-Jeung Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders |
title | Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders |
title_full | Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders |
title_fullStr | Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders |
title_full_unstemmed | Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders |
title_short | Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders |
title_sort | role of phytoconstituents as ppar agonists: implications for neurodegenerative disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698906/ https://www.ncbi.nlm.nih.gov/pubmed/34944727 http://dx.doi.org/10.3390/biomedicines9121914 |
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