Hydrogen Bond Arrangement Is Shown to Differ in Coexisting Phases of Aqueous Two-Phase Systems

Analysis by attenuated total reflection–Fourier transform infrared spectroscopy shows that each coexisting phase in aqueous two-phase systems has a different arrangement of hydrogen bonds. Specific arrangements vary for systems formed by different solutes. The hydrogen bond arrangement is shown to c...

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Autores principales: Madeira, Pedro P., Titus, Amber R., Ferreira, Luisa A., Belgovskiy, Alexander I., Mann, Elizabeth K., Mann, Jay Adin, Meyer, William V., Smart, Anthony E., Uversky, Vladimir N., Zaslavsky, Boris Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698934/
https://www.ncbi.nlm.nih.gov/pubmed/34944431
http://dx.doi.org/10.3390/biom11121787
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author Madeira, Pedro P.
Titus, Amber R.
Ferreira, Luisa A.
Belgovskiy, Alexander I.
Mann, Elizabeth K.
Mann, Jay Adin
Meyer, William V.
Smart, Anthony E.
Uversky, Vladimir N.
Zaslavsky, Boris Y.
author_facet Madeira, Pedro P.
Titus, Amber R.
Ferreira, Luisa A.
Belgovskiy, Alexander I.
Mann, Elizabeth K.
Mann, Jay Adin
Meyer, William V.
Smart, Anthony E.
Uversky, Vladimir N.
Zaslavsky, Boris Y.
author_sort Madeira, Pedro P.
collection PubMed
description Analysis by attenuated total reflection–Fourier transform infrared spectroscopy shows that each coexisting phase in aqueous two-phase systems has a different arrangement of hydrogen bonds. Specific arrangements vary for systems formed by different solutes. The hydrogen bond arrangement is shown to correlate with differences in hydrophobic and electrostatic properties of the different phases of five specific systems, four formed by two polymers and one by a single polymer and salt. The results presented here suggest that the arrangement of hydrogen bonds may be an important factor in phase separation.
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spelling pubmed-86989342021-12-24 Hydrogen Bond Arrangement Is Shown to Differ in Coexisting Phases of Aqueous Two-Phase Systems Madeira, Pedro P. Titus, Amber R. Ferreira, Luisa A. Belgovskiy, Alexander I. Mann, Elizabeth K. Mann, Jay Adin Meyer, William V. Smart, Anthony E. Uversky, Vladimir N. Zaslavsky, Boris Y. Biomolecules Article Analysis by attenuated total reflection–Fourier transform infrared spectroscopy shows that each coexisting phase in aqueous two-phase systems has a different arrangement of hydrogen bonds. Specific arrangements vary for systems formed by different solutes. The hydrogen bond arrangement is shown to correlate with differences in hydrophobic and electrostatic properties of the different phases of five specific systems, four formed by two polymers and one by a single polymer and salt. The results presented here suggest that the arrangement of hydrogen bonds may be an important factor in phase separation. MDPI 2021-11-30 /pmc/articles/PMC8698934/ /pubmed/34944431 http://dx.doi.org/10.3390/biom11121787 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Madeira, Pedro P.
Titus, Amber R.
Ferreira, Luisa A.
Belgovskiy, Alexander I.
Mann, Elizabeth K.
Mann, Jay Adin
Meyer, William V.
Smart, Anthony E.
Uversky, Vladimir N.
Zaslavsky, Boris Y.
Hydrogen Bond Arrangement Is Shown to Differ in Coexisting Phases of Aqueous Two-Phase Systems
title Hydrogen Bond Arrangement Is Shown to Differ in Coexisting Phases of Aqueous Two-Phase Systems
title_full Hydrogen Bond Arrangement Is Shown to Differ in Coexisting Phases of Aqueous Two-Phase Systems
title_fullStr Hydrogen Bond Arrangement Is Shown to Differ in Coexisting Phases of Aqueous Two-Phase Systems
title_full_unstemmed Hydrogen Bond Arrangement Is Shown to Differ in Coexisting Phases of Aqueous Two-Phase Systems
title_short Hydrogen Bond Arrangement Is Shown to Differ in Coexisting Phases of Aqueous Two-Phase Systems
title_sort hydrogen bond arrangement is shown to differ in coexisting phases of aqueous two-phase systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698934/
https://www.ncbi.nlm.nih.gov/pubmed/34944431
http://dx.doi.org/10.3390/biom11121787
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