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Health Benefits and Pharmacological Properties of Carvone
Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Curr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698960/ https://www.ncbi.nlm.nih.gov/pubmed/34944447 http://dx.doi.org/10.3390/biom11121803 |
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author | Bouyahya, Abdelhakim Mechchate, Hamza Benali, Taoufiq Ghchime, Rokia Charfi, Saoulajan Balahbib, Abdelaali Burkov, Pavel Shariati, Mohammad Ali Lorenzo, Jose M. Omari, Nasreddine El |
author_facet | Bouyahya, Abdelhakim Mechchate, Hamza Benali, Taoufiq Ghchime, Rokia Charfi, Saoulajan Balahbib, Abdelaali Burkov, Pavel Shariati, Mohammad Ali Lorenzo, Jose M. Omari, Nasreddine El |
author_sort | Bouyahya, Abdelhakim |
collection | PubMed |
description | Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested. |
format | Online Article Text |
id | pubmed-8698960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86989602021-12-24 Health Benefits and Pharmacological Properties of Carvone Bouyahya, Abdelhakim Mechchate, Hamza Benali, Taoufiq Ghchime, Rokia Charfi, Saoulajan Balahbib, Abdelaali Burkov, Pavel Shariati, Mohammad Ali Lorenzo, Jose M. Omari, Nasreddine El Biomolecules Review Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested. MDPI 2021-12-01 /pmc/articles/PMC8698960/ /pubmed/34944447 http://dx.doi.org/10.3390/biom11121803 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bouyahya, Abdelhakim Mechchate, Hamza Benali, Taoufiq Ghchime, Rokia Charfi, Saoulajan Balahbib, Abdelaali Burkov, Pavel Shariati, Mohammad Ali Lorenzo, Jose M. Omari, Nasreddine El Health Benefits and Pharmacological Properties of Carvone |
title | Health Benefits and Pharmacological Properties of Carvone |
title_full | Health Benefits and Pharmacological Properties of Carvone |
title_fullStr | Health Benefits and Pharmacological Properties of Carvone |
title_full_unstemmed | Health Benefits and Pharmacological Properties of Carvone |
title_short | Health Benefits and Pharmacological Properties of Carvone |
title_sort | health benefits and pharmacological properties of carvone |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698960/ https://www.ncbi.nlm.nih.gov/pubmed/34944447 http://dx.doi.org/10.3390/biom11121803 |
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