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Health Benefits and Pharmacological Properties of Carvone

Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Curr...

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Autores principales: Bouyahya, Abdelhakim, Mechchate, Hamza, Benali, Taoufiq, Ghchime, Rokia, Charfi, Saoulajan, Balahbib, Abdelaali, Burkov, Pavel, Shariati, Mohammad Ali, Lorenzo, Jose M., Omari, Nasreddine El
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698960/
https://www.ncbi.nlm.nih.gov/pubmed/34944447
http://dx.doi.org/10.3390/biom11121803
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author Bouyahya, Abdelhakim
Mechchate, Hamza
Benali, Taoufiq
Ghchime, Rokia
Charfi, Saoulajan
Balahbib, Abdelaali
Burkov, Pavel
Shariati, Mohammad Ali
Lorenzo, Jose M.
Omari, Nasreddine El
author_facet Bouyahya, Abdelhakim
Mechchate, Hamza
Benali, Taoufiq
Ghchime, Rokia
Charfi, Saoulajan
Balahbib, Abdelaali
Burkov, Pavel
Shariati, Mohammad Ali
Lorenzo, Jose M.
Omari, Nasreddine El
author_sort Bouyahya, Abdelhakim
collection PubMed
description Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested.
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spelling pubmed-86989602021-12-24 Health Benefits and Pharmacological Properties of Carvone Bouyahya, Abdelhakim Mechchate, Hamza Benali, Taoufiq Ghchime, Rokia Charfi, Saoulajan Balahbib, Abdelaali Burkov, Pavel Shariati, Mohammad Ali Lorenzo, Jose M. Omari, Nasreddine El Biomolecules Review Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested. MDPI 2021-12-01 /pmc/articles/PMC8698960/ /pubmed/34944447 http://dx.doi.org/10.3390/biom11121803 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bouyahya, Abdelhakim
Mechchate, Hamza
Benali, Taoufiq
Ghchime, Rokia
Charfi, Saoulajan
Balahbib, Abdelaali
Burkov, Pavel
Shariati, Mohammad Ali
Lorenzo, Jose M.
Omari, Nasreddine El
Health Benefits and Pharmacological Properties of Carvone
title Health Benefits and Pharmacological Properties of Carvone
title_full Health Benefits and Pharmacological Properties of Carvone
title_fullStr Health Benefits and Pharmacological Properties of Carvone
title_full_unstemmed Health Benefits and Pharmacological Properties of Carvone
title_short Health Benefits and Pharmacological Properties of Carvone
title_sort health benefits and pharmacological properties of carvone
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698960/
https://www.ncbi.nlm.nih.gov/pubmed/34944447
http://dx.doi.org/10.3390/biom11121803
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