Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on their cell surface. Due to this, SSTR and somatos...

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Autores principales: del Olmo-Garcia, Maria Isabel, Prado-Wohlwend, Stefan, Andres, Alexia, Soriano, Jose M., Bello, Pilar, Merino-Torres, Juan Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699000/
https://www.ncbi.nlm.nih.gov/pubmed/34944626
http://dx.doi.org/10.3390/biomedicines9121810
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author del Olmo-Garcia, Maria Isabel
Prado-Wohlwend, Stefan
Andres, Alexia
Soriano, Jose M.
Bello, Pilar
Merino-Torres, Juan Francisco
author_facet del Olmo-Garcia, Maria Isabel
Prado-Wohlwend, Stefan
Andres, Alexia
Soriano, Jose M.
Bello, Pilar
Merino-Torres, Juan Francisco
author_sort del Olmo-Garcia, Maria Isabel
collection PubMed
description Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on their cell surface. Due to this, SSTR and somatostatin have been a large subject of interest in the discovery of potential biomarkers and treatment options for the disease. The aim of this review is to describe the molecular characteristics of somatostatin and somatostatin receptors and its application in diagnosis and therapy on patients with NENs as well as the use in the near future of somatostatin antagonists.
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spelling pubmed-86990002021-12-24 Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms del Olmo-Garcia, Maria Isabel Prado-Wohlwend, Stefan Andres, Alexia Soriano, Jose M. Bello, Pilar Merino-Torres, Juan Francisco Biomedicines Review Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on their cell surface. Due to this, SSTR and somatostatin have been a large subject of interest in the discovery of potential biomarkers and treatment options for the disease. The aim of this review is to describe the molecular characteristics of somatostatin and somatostatin receptors and its application in diagnosis and therapy on patients with NENs as well as the use in the near future of somatostatin antagonists. MDPI 2021-12-01 /pmc/articles/PMC8699000/ /pubmed/34944626 http://dx.doi.org/10.3390/biomedicines9121810 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
del Olmo-Garcia, Maria Isabel
Prado-Wohlwend, Stefan
Andres, Alexia
Soriano, Jose M.
Bello, Pilar
Merino-Torres, Juan Francisco
Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
title Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
title_full Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
title_fullStr Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
title_full_unstemmed Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
title_short Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
title_sort somatostatin and somatostatin receptors: from signaling to clinical applications in neuroendocrine neoplasms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699000/
https://www.ncbi.nlm.nih.gov/pubmed/34944626
http://dx.doi.org/10.3390/biomedicines9121810
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