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Which Properties Allow Ligands to Open and Bind to the Transient Binding Pocket of Human Aldose Reductase?
The transient specificity pocket of aldose reductase only opens in response to specific ligands. This pocket may offer an advantage for the development of novel, more selective ligands for proteins with similar topology that lack such an adaptive pocket. Our aim was to elucidate which properties all...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699021/ https://www.ncbi.nlm.nih.gov/pubmed/34944481 http://dx.doi.org/10.3390/biom11121837 |