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Probing the Influence of Single-Site Mutations in the Central Cross-β Region of Amyloid β (1–40) Peptides

Amyloid β (Aβ) is a peptide known to form amyloid fibrils in the brain of patients suffering from Alzheimer’s disease. A complete mechanistic understanding how Aβ peptides form neurotoxic assemblies and how they kill neurons has not yet been achieved. Previous analysis of various Aβ(40) mutants coul...

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Detalles Bibliográficos
Autores principales:	Fritzsch, Jacob, Korn, Alexander, Surendran, Dayana, Krueger, Martin, Scheidt, Holger A., Mote, Kaustubh R., Madhu, Perunthiruthy K., Maiti, Sudipta, Huster, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699037/ https://www.ncbi.nlm.nih.gov/pubmed/34944492 http://dx.doi.org/10.3390/biom11121848

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