The Role of NRF2 in Mycobacterial Infection

The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important...

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Autores principales: Matsuyama, Masashi, Nonaka, Mizu, Nakajima, Masayuki, Morishima, Yuko, Ishii, Yukio, Hizawa, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699052/
https://www.ncbi.nlm.nih.gov/pubmed/34942964
http://dx.doi.org/10.3390/antiox10121861
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author Matsuyama, Masashi
Nonaka, Mizu
Nakajima, Masayuki
Morishima, Yuko
Ishii, Yukio
Hizawa, Nobuyuki
author_facet Matsuyama, Masashi
Nonaka, Mizu
Nakajima, Masayuki
Morishima, Yuko
Ishii, Yukio
Hizawa, Nobuyuki
author_sort Matsuyama, Masashi
collection PubMed
description The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important issue for treatment. To discover and develop new efficacious anti-mycobacterial treatments, it is important to understand the host-defense mechanisms against mycobacterial infection. Nuclear erythroid 2 p45-related factor-2 (NRF2) is known to be a major regulator of various antioxidant response element (ARE)-driven cytoprotective gene expressions, and its protective role has been demonstrated in infections. However, there are not many papers or reviews regarding the role of NRF2 in mycobacterial infectious disease. Therefore, this review focuses on the role of NRF2 in the pathogenesis of Mycobacterium tuberculosis and Mycobacterium avium infection.
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spelling pubmed-86990522021-12-24 The Role of NRF2 in Mycobacterial Infection Matsuyama, Masashi Nonaka, Mizu Nakajima, Masayuki Morishima, Yuko Ishii, Yukio Hizawa, Nobuyuki Antioxidants (Basel) Review The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important issue for treatment. To discover and develop new efficacious anti-mycobacterial treatments, it is important to understand the host-defense mechanisms against mycobacterial infection. Nuclear erythroid 2 p45-related factor-2 (NRF2) is known to be a major regulator of various antioxidant response element (ARE)-driven cytoprotective gene expressions, and its protective role has been demonstrated in infections. However, there are not many papers or reviews regarding the role of NRF2 in mycobacterial infectious disease. Therefore, this review focuses on the role of NRF2 in the pathogenesis of Mycobacterium tuberculosis and Mycobacterium avium infection. MDPI 2021-11-23 /pmc/articles/PMC8699052/ /pubmed/34942964 http://dx.doi.org/10.3390/antiox10121861 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matsuyama, Masashi
Nonaka, Mizu
Nakajima, Masayuki
Morishima, Yuko
Ishii, Yukio
Hizawa, Nobuyuki
The Role of NRF2 in Mycobacterial Infection
title The Role of NRF2 in Mycobacterial Infection
title_full The Role of NRF2 in Mycobacterial Infection
title_fullStr The Role of NRF2 in Mycobacterial Infection
title_full_unstemmed The Role of NRF2 in Mycobacterial Infection
title_short The Role of NRF2 in Mycobacterial Infection
title_sort role of nrf2 in mycobacterial infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699052/
https://www.ncbi.nlm.nih.gov/pubmed/34942964
http://dx.doi.org/10.3390/antiox10121861
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