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Population Pharmacokinetic Model-Based Evaluation of Intact Oxaliplatin in Rats with Acute Kidney Injury

SIMPLE SUMMARY: Acute kidney injury (AKI) complicates the dose setting of oxaliplatin (L-OHP), making it difficult to continue treatment cycles and retain antitumor efficacies with minimum L-OHP-related toxicities. Our study aimed to assess the impact of AKI on the pharmacokinetics of intact L-OHP a...

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Detalles Bibliográficos
Autores principales:	Kobuchi, Shinji, Kai, Miyu, Ito, Yukako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699120/ https://www.ncbi.nlm.nih.gov/pubmed/34945005 http://dx.doi.org/10.3390/cancers13246382

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