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Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1

Cognitive impairments and social-function deficits are severe complaints in neurofibromatosis type 1 (NF1) patients. Empathetic pain perception may be disrupted in NF1 patients because of high-level cognitive deficits. This study investigated the empathy profiles of adult patients with NF1, especial...

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Autores principales: Xue, Hai, Wu, Qiong, Yang, Zhijun, Wang, Bo, Wang, Xingchao, Liu, Pinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699130/
https://www.ncbi.nlm.nih.gov/pubmed/34942892
http://dx.doi.org/10.3390/brainsci11121591
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author Xue, Hai
Wu, Qiong
Yang, Zhijun
Wang, Bo
Wang, Xingchao
Liu, Pinan
author_facet Xue, Hai
Wu, Qiong
Yang, Zhijun
Wang, Bo
Wang, Xingchao
Liu, Pinan
author_sort Xue, Hai
collection PubMed
description Cognitive impairments and social-function deficits are severe complaints in neurofibromatosis type 1 (NF1) patients. Empathetic pain perception may be disrupted in NF1 patients because of high-level cognitive deficits. This study investigated the empathy profiles of adult patients with NF1, especially concerning whether explicit and implicit empathetic pain perception are abnormal in this population. We examined empathetic pain perception through a paradigm based on perceiving another person’s pain; in this task, patients were required to make judgments about the presence of pain or the laterality of the body part, as shown in a picture. Twenty NF1 patients without obvious social or communication difficulties completed the task, and the results were compared with results from the normal controls (NCs). Regarding explicit empathetic pain processing, i.e., judging the presence of “pain” or “no pain”, there were no significant differences between patients and controls in accuracy or reaction time. However, in implicit empathetic processing, i.e., judging the laterality of “pain” or “no-pain” pictures, NF1 patients had significantly lower accuracy (p = 0.038) and significantly higher reaction times (p = 0.004) than the NCs. These results were consistent with those of a previous study showing that high-level cognitive deficits were prominent in NF1 patients when performing challenging tasks. The mechanisms and related brain network activity underlying these deficits should receive attention in the future.
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spelling pubmed-86991302021-12-24 Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1 Xue, Hai Wu, Qiong Yang, Zhijun Wang, Bo Wang, Xingchao Liu, Pinan Brain Sci Article Cognitive impairments and social-function deficits are severe complaints in neurofibromatosis type 1 (NF1) patients. Empathetic pain perception may be disrupted in NF1 patients because of high-level cognitive deficits. This study investigated the empathy profiles of adult patients with NF1, especially concerning whether explicit and implicit empathetic pain perception are abnormal in this population. We examined empathetic pain perception through a paradigm based on perceiving another person’s pain; in this task, patients were required to make judgments about the presence of pain or the laterality of the body part, as shown in a picture. Twenty NF1 patients without obvious social or communication difficulties completed the task, and the results were compared with results from the normal controls (NCs). Regarding explicit empathetic pain processing, i.e., judging the presence of “pain” or “no pain”, there were no significant differences between patients and controls in accuracy or reaction time. However, in implicit empathetic processing, i.e., judging the laterality of “pain” or “no-pain” pictures, NF1 patients had significantly lower accuracy (p = 0.038) and significantly higher reaction times (p = 0.004) than the NCs. These results were consistent with those of a previous study showing that high-level cognitive deficits were prominent in NF1 patients when performing challenging tasks. The mechanisms and related brain network activity underlying these deficits should receive attention in the future. MDPI 2021-11-30 /pmc/articles/PMC8699130/ /pubmed/34942892 http://dx.doi.org/10.3390/brainsci11121591 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xue, Hai
Wu, Qiong
Yang, Zhijun
Wang, Bo
Wang, Xingchao
Liu, Pinan
Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1
title Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1
title_full Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1
title_fullStr Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1
title_full_unstemmed Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1
title_short Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1
title_sort dissociated deficits between explicit and implicit empathetic pain perception in neurofibromatosis type 1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699130/
https://www.ncbi.nlm.nih.gov/pubmed/34942892
http://dx.doi.org/10.3390/brainsci11121591
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