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COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation
Background: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who underwent post-acute intensive rehabilitation after COVID-19. Met...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699176/ https://www.ncbi.nlm.nih.gov/pubmed/34942912 http://dx.doi.org/10.3390/brainsci11121611 |
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author | Bagnato, Sergio Ferraro, Manfredi Boccagni, Cristina Battaglia, Gianluca D’Agostino, Tiziana Prestandrea, Caterina Bellavia, Marina Angela Rubino, Francesca |
author_facet | Bagnato, Sergio Ferraro, Manfredi Boccagni, Cristina Battaglia, Gianluca D’Agostino, Tiziana Prestandrea, Caterina Bellavia, Marina Angela Rubino, Francesca |
author_sort | Bagnato, Sergio |
collection | PubMed |
description | Background: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who underwent post-acute intensive rehabilitation after COVID-19. Methods: Clinical and neurophysiological evaluations, including nerve conduction studies and electromyography, were performed on 21 consecutive patients admitted for rehabilitation after COVID-19. Results: Clinical signs suggesting muscle or nerve involvement (weakness, reduced deep tendon reflexes, impaired sensitivity, abnormal gait) were found in 19 patients. Neurophysiological examinations confirmed neuromuscular involvement in 17 patients: a likely association of critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) was found in 5 patients; CIM alone was found in 4 patients; axonal sensory-motor polyneuropathy was found in 4 patients (CIP in 2 patients, metabolic polyneuropathy in 2 patients); Guillain-Barré syndrome was found in 2 patients (classical demyelinating sensory-motor polyneuropathy and acute motor axonal neuropathy, respectively); peroneal nerve injury was found in 1 patient; and pre-existing L4 radiculopathy was found in 1 patient. Conclusions: Neuromuscular involvement is a very common finding among patients admitted for rehabilitation after COVID-19, and proper investigation should be conducted when muscle or nerve injury is suspected for adequate rehabilitative strategy planning. |
format | Online Article Text |
id | pubmed-8699176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86991762021-12-24 COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation Bagnato, Sergio Ferraro, Manfredi Boccagni, Cristina Battaglia, Gianluca D’Agostino, Tiziana Prestandrea, Caterina Bellavia, Marina Angela Rubino, Francesca Brain Sci Communication Background: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who underwent post-acute intensive rehabilitation after COVID-19. Methods: Clinical and neurophysiological evaluations, including nerve conduction studies and electromyography, were performed on 21 consecutive patients admitted for rehabilitation after COVID-19. Results: Clinical signs suggesting muscle or nerve involvement (weakness, reduced deep tendon reflexes, impaired sensitivity, abnormal gait) were found in 19 patients. Neurophysiological examinations confirmed neuromuscular involvement in 17 patients: a likely association of critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) was found in 5 patients; CIM alone was found in 4 patients; axonal sensory-motor polyneuropathy was found in 4 patients (CIP in 2 patients, metabolic polyneuropathy in 2 patients); Guillain-Barré syndrome was found in 2 patients (classical demyelinating sensory-motor polyneuropathy and acute motor axonal neuropathy, respectively); peroneal nerve injury was found in 1 patient; and pre-existing L4 radiculopathy was found in 1 patient. Conclusions: Neuromuscular involvement is a very common finding among patients admitted for rehabilitation after COVID-19, and proper investigation should be conducted when muscle or nerve injury is suspected for adequate rehabilitative strategy planning. MDPI 2021-12-06 /pmc/articles/PMC8699176/ /pubmed/34942912 http://dx.doi.org/10.3390/brainsci11121611 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Bagnato, Sergio Ferraro, Manfredi Boccagni, Cristina Battaglia, Gianluca D’Agostino, Tiziana Prestandrea, Caterina Bellavia, Marina Angela Rubino, Francesca COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
title | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
title_full | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
title_fullStr | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
title_full_unstemmed | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
title_short | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
title_sort | covid-19 neuromuscular involvement in post-acute rehabilitation |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699176/ https://www.ncbi.nlm.nih.gov/pubmed/34942912 http://dx.doi.org/10.3390/brainsci11121611 |
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