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COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation

Background: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who underwent post-acute intensive rehabilitation after COVID-19. Met...

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Autores principales: Bagnato, Sergio, Ferraro, Manfredi, Boccagni, Cristina, Battaglia, Gianluca, D’Agostino, Tiziana, Prestandrea, Caterina, Bellavia, Marina Angela, Rubino, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699176/
https://www.ncbi.nlm.nih.gov/pubmed/34942912
http://dx.doi.org/10.3390/brainsci11121611
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author Bagnato, Sergio
Ferraro, Manfredi
Boccagni, Cristina
Battaglia, Gianluca
D’Agostino, Tiziana
Prestandrea, Caterina
Bellavia, Marina Angela
Rubino, Francesca
author_facet Bagnato, Sergio
Ferraro, Manfredi
Boccagni, Cristina
Battaglia, Gianluca
D’Agostino, Tiziana
Prestandrea, Caterina
Bellavia, Marina Angela
Rubino, Francesca
author_sort Bagnato, Sergio
collection PubMed
description Background: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who underwent post-acute intensive rehabilitation after COVID-19. Methods: Clinical and neurophysiological evaluations, including nerve conduction studies and electromyography, were performed on 21 consecutive patients admitted for rehabilitation after COVID-19. Results: Clinical signs suggesting muscle or nerve involvement (weakness, reduced deep tendon reflexes, impaired sensitivity, abnormal gait) were found in 19 patients. Neurophysiological examinations confirmed neuromuscular involvement in 17 patients: a likely association of critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) was found in 5 patients; CIM alone was found in 4 patients; axonal sensory-motor polyneuropathy was found in 4 patients (CIP in 2 patients, metabolic polyneuropathy in 2 patients); Guillain-Barré syndrome was found in 2 patients (classical demyelinating sensory-motor polyneuropathy and acute motor axonal neuropathy, respectively); peroneal nerve injury was found in 1 patient; and pre-existing L4 radiculopathy was found in 1 patient. Conclusions: Neuromuscular involvement is a very common finding among patients admitted for rehabilitation after COVID-19, and proper investigation should be conducted when muscle or nerve injury is suspected for adequate rehabilitative strategy planning.
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spelling pubmed-86991762021-12-24 COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation Bagnato, Sergio Ferraro, Manfredi Boccagni, Cristina Battaglia, Gianluca D’Agostino, Tiziana Prestandrea, Caterina Bellavia, Marina Angela Rubino, Francesca Brain Sci Communication Background: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who underwent post-acute intensive rehabilitation after COVID-19. Methods: Clinical and neurophysiological evaluations, including nerve conduction studies and electromyography, were performed on 21 consecutive patients admitted for rehabilitation after COVID-19. Results: Clinical signs suggesting muscle or nerve involvement (weakness, reduced deep tendon reflexes, impaired sensitivity, abnormal gait) were found in 19 patients. Neurophysiological examinations confirmed neuromuscular involvement in 17 patients: a likely association of critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) was found in 5 patients; CIM alone was found in 4 patients; axonal sensory-motor polyneuropathy was found in 4 patients (CIP in 2 patients, metabolic polyneuropathy in 2 patients); Guillain-Barré syndrome was found in 2 patients (classical demyelinating sensory-motor polyneuropathy and acute motor axonal neuropathy, respectively); peroneal nerve injury was found in 1 patient; and pre-existing L4 radiculopathy was found in 1 patient. Conclusions: Neuromuscular involvement is a very common finding among patients admitted for rehabilitation after COVID-19, and proper investigation should be conducted when muscle or nerve injury is suspected for adequate rehabilitative strategy planning. MDPI 2021-12-06 /pmc/articles/PMC8699176/ /pubmed/34942912 http://dx.doi.org/10.3390/brainsci11121611 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Bagnato, Sergio
Ferraro, Manfredi
Boccagni, Cristina
Battaglia, Gianluca
D’Agostino, Tiziana
Prestandrea, Caterina
Bellavia, Marina Angela
Rubino, Francesca
COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation
title COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation
title_full COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation
title_fullStr COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation
title_full_unstemmed COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation
title_short COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation
title_sort covid-19 neuromuscular involvement in post-acute rehabilitation
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699176/
https://www.ncbi.nlm.nih.gov/pubmed/34942912
http://dx.doi.org/10.3390/brainsci11121611
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