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Insight into the Double-Edged Role of Ferroptosis in Disease
Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highligh...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699194/ https://www.ncbi.nlm.nih.gov/pubmed/34944434 http://dx.doi.org/10.3390/biom11121790 |
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author | Zhang, Lei Jia, Ruohan Li, Huizhen Yu, Huarun Ren, Keke Jia, Shuangshuang Li, Yanzhang Wang, Qun |
author_facet | Zhang, Lei Jia, Ruohan Li, Huizhen Yu, Huarun Ren, Keke Jia, Shuangshuang Li, Yanzhang Wang, Qun |
author_sort | Zhang, Lei |
collection | PubMed |
description | Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis. |
format | Online Article Text |
id | pubmed-8699194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86991942021-12-24 Insight into the Double-Edged Role of Ferroptosis in Disease Zhang, Lei Jia, Ruohan Li, Huizhen Yu, Huarun Ren, Keke Jia, Shuangshuang Li, Yanzhang Wang, Qun Biomolecules Review Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis. MDPI 2021-11-30 /pmc/articles/PMC8699194/ /pubmed/34944434 http://dx.doi.org/10.3390/biom11121790 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Lei Jia, Ruohan Li, Huizhen Yu, Huarun Ren, Keke Jia, Shuangshuang Li, Yanzhang Wang, Qun Insight into the Double-Edged Role of Ferroptosis in Disease |
title | Insight into the Double-Edged Role of Ferroptosis in Disease |
title_full | Insight into the Double-Edged Role of Ferroptosis in Disease |
title_fullStr | Insight into the Double-Edged Role of Ferroptosis in Disease |
title_full_unstemmed | Insight into the Double-Edged Role of Ferroptosis in Disease |
title_short | Insight into the Double-Edged Role of Ferroptosis in Disease |
title_sort | insight into the double-edged role of ferroptosis in disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699194/ https://www.ncbi.nlm.nih.gov/pubmed/34944434 http://dx.doi.org/10.3390/biom11121790 |
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