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Small Extracellular Vesicles and COVID19—Using the “Trojan Horse” to Tackle the Giant

The COVID-19 pandemic is a global challenge, demanding researchers address different approaches in relation to prevention, diagnostics and therapeutics. Amongst the many tactics of tackling these therapeutic challenges, small extracellular vesicles (sEVs) or exosomes are emerging as a new frontier i...

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Autores principales: Borowiec, Blanka Maria, Angelova Volponi, Ana, Mozdziak, Paul, Kempisty, Bartosz, Dyszkiewicz-Konwińska, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699232/
https://www.ncbi.nlm.nih.gov/pubmed/34943891
http://dx.doi.org/10.3390/cells10123383
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author Borowiec, Blanka Maria
Angelova Volponi, Ana
Mozdziak, Paul
Kempisty, Bartosz
Dyszkiewicz-Konwińska, Marta
author_facet Borowiec, Blanka Maria
Angelova Volponi, Ana
Mozdziak, Paul
Kempisty, Bartosz
Dyszkiewicz-Konwińska, Marta
author_sort Borowiec, Blanka Maria
collection PubMed
description The COVID-19 pandemic is a global challenge, demanding researchers address different approaches in relation to prevention, diagnostics and therapeutics. Amongst the many tactics of tackling these therapeutic challenges, small extracellular vesicles (sEVs) or exosomes are emerging as a new frontier in the field of ameliorating viral infections. Exosomes are part of extracellular vesicles (EVs)—spherical biological structures with a lipid bilayer of a diameter of up to 5000 nm, which are released into the intercellular space by most types of eukaryotic cells, both in physiological and pathological states. EVs share structural similarities to viruses, such as small size, common mechanisms of biogenesis and mechanisms for cell entry. The role of EVs in promoting the viral spread by evading the immune response of the host, which is exhibited by retroviruses, indicates the potential for further investigation and possible manipulation of these processes when tackling the spread and treatment of COVID-19. The following paper introduces the topic of the use of exosomes in the treatment of viral infections, and presents the future prospects for the use of these EVs.
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spelling pubmed-86992322021-12-24 Small Extracellular Vesicles and COVID19—Using the “Trojan Horse” to Tackle the Giant Borowiec, Blanka Maria Angelova Volponi, Ana Mozdziak, Paul Kempisty, Bartosz Dyszkiewicz-Konwińska, Marta Cells Review The COVID-19 pandemic is a global challenge, demanding researchers address different approaches in relation to prevention, diagnostics and therapeutics. Amongst the many tactics of tackling these therapeutic challenges, small extracellular vesicles (sEVs) or exosomes are emerging as a new frontier in the field of ameliorating viral infections. Exosomes are part of extracellular vesicles (EVs)—spherical biological structures with a lipid bilayer of a diameter of up to 5000 nm, which are released into the intercellular space by most types of eukaryotic cells, both in physiological and pathological states. EVs share structural similarities to viruses, such as small size, common mechanisms of biogenesis and mechanisms for cell entry. The role of EVs in promoting the viral spread by evading the immune response of the host, which is exhibited by retroviruses, indicates the potential for further investigation and possible manipulation of these processes when tackling the spread and treatment of COVID-19. The following paper introduces the topic of the use of exosomes in the treatment of viral infections, and presents the future prospects for the use of these EVs. MDPI 2021-12-01 /pmc/articles/PMC8699232/ /pubmed/34943891 http://dx.doi.org/10.3390/cells10123383 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Borowiec, Blanka Maria
Angelova Volponi, Ana
Mozdziak, Paul
Kempisty, Bartosz
Dyszkiewicz-Konwińska, Marta
Small Extracellular Vesicles and COVID19—Using the “Trojan Horse” to Tackle the Giant
title Small Extracellular Vesicles and COVID19—Using the “Trojan Horse” to Tackle the Giant
title_full Small Extracellular Vesicles and COVID19—Using the “Trojan Horse” to Tackle the Giant
title_fullStr Small Extracellular Vesicles and COVID19—Using the “Trojan Horse” to Tackle the Giant
title_full_unstemmed Small Extracellular Vesicles and COVID19—Using the “Trojan Horse” to Tackle the Giant
title_short Small Extracellular Vesicles and COVID19—Using the “Trojan Horse” to Tackle the Giant
title_sort small extracellular vesicles and covid19—using the “trojan horse” to tackle the giant
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699232/
https://www.ncbi.nlm.nih.gov/pubmed/34943891
http://dx.doi.org/10.3390/cells10123383
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