Cargando…

Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm

Abdominal aortic aneurysm (AAA) is an immune-mediated disease with a genetic component. The multifactorial pathophysiology is not clear and there is still no pharmacotherapy to slow the growth of aneurysms. The signal integration of cell-surface KIRs (killer cell immunoglobulin-like receptors) with...

Descripción completa

Detalles Bibliográficos
Autores principales: Dubis, Joanna, Niepiekło-Miniewska, Wanda, Jędruchniewicz, Natalia, Sobczyński, Maciej, Witkiewicz, Wojciech, Zapotoczny, Norbert, Kuśnierczyk, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699266/
https://www.ncbi.nlm.nih.gov/pubmed/34943866
http://dx.doi.org/10.3390/cells10123357
_version_ 1784620473042075648
author Dubis, Joanna
Niepiekło-Miniewska, Wanda
Jędruchniewicz, Natalia
Sobczyński, Maciej
Witkiewicz, Wojciech
Zapotoczny, Norbert
Kuśnierczyk, Piotr
author_facet Dubis, Joanna
Niepiekło-Miniewska, Wanda
Jędruchniewicz, Natalia
Sobczyński, Maciej
Witkiewicz, Wojciech
Zapotoczny, Norbert
Kuśnierczyk, Piotr
author_sort Dubis, Joanna
collection PubMed
description Abdominal aortic aneurysm (AAA) is an immune-mediated disease with a genetic component. The multifactorial pathophysiology is not clear and there is still no pharmacotherapy to slow the growth of aneurysms. The signal integration of cell-surface KIRs (killer cell immunoglobulin-like receptors) with HLA (ligands, human leukocyte class I antigen molecules) modulates the activity of natural killer immune cells. The genetic diversity of the KIR/HLA system is associated with the risk of immune disorders. This study was a multivariate analysis of the association between genetic variants of KIRs, HLA ligands, clinical data and AAA formation. Genotyping was performed by single polymerase chain reaction with sequence-specific primers using commercial assays. Patients with HLA-A-Bw4 have a larger aneurysm by an average of 4 mm (p = 0.008). We observed a relationship between aneurysm diameter and BMI in patients with AAA and co-existing CAD; its shape was determined by the presence of HLA-A-Bw4. There was also a nearly 10% difference in KIR3DL1 allele frequency between the study and control groups. High expression of the cell surface receptor KIR3DL1 may protect, to some extent, against AAA. The presence of HLA-A-Bw4 may affect the rate of aneurysm growth and represents a potential regional pathogenetic risk of autoimmune injury to the aneurysmal aorta.
format Online
Article
Text
id pubmed-8699266
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86992662021-12-24 Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm Dubis, Joanna Niepiekło-Miniewska, Wanda Jędruchniewicz, Natalia Sobczyński, Maciej Witkiewicz, Wojciech Zapotoczny, Norbert Kuśnierczyk, Piotr Cells Article Abdominal aortic aneurysm (AAA) is an immune-mediated disease with a genetic component. The multifactorial pathophysiology is not clear and there is still no pharmacotherapy to slow the growth of aneurysms. The signal integration of cell-surface KIRs (killer cell immunoglobulin-like receptors) with HLA (ligands, human leukocyte class I antigen molecules) modulates the activity of natural killer immune cells. The genetic diversity of the KIR/HLA system is associated with the risk of immune disorders. This study was a multivariate analysis of the association between genetic variants of KIRs, HLA ligands, clinical data and AAA formation. Genotyping was performed by single polymerase chain reaction with sequence-specific primers using commercial assays. Patients with HLA-A-Bw4 have a larger aneurysm by an average of 4 mm (p = 0.008). We observed a relationship between aneurysm diameter and BMI in patients with AAA and co-existing CAD; its shape was determined by the presence of HLA-A-Bw4. There was also a nearly 10% difference in KIR3DL1 allele frequency between the study and control groups. High expression of the cell surface receptor KIR3DL1 may protect, to some extent, against AAA. The presence of HLA-A-Bw4 may affect the rate of aneurysm growth and represents a potential regional pathogenetic risk of autoimmune injury to the aneurysmal aorta. MDPI 2021-11-30 /pmc/articles/PMC8699266/ /pubmed/34943866 http://dx.doi.org/10.3390/cells10123357 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dubis, Joanna
Niepiekło-Miniewska, Wanda
Jędruchniewicz, Natalia
Sobczyński, Maciej
Witkiewicz, Wojciech
Zapotoczny, Norbert
Kuśnierczyk, Piotr
Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm
title Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm
title_full Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm
title_fullStr Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm
title_full_unstemmed Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm
title_short Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm
title_sort associations of genes for killer cell immunoglobulin-like receptors and their human leukocyte antigen-a/b/c ligands with abdominal aortic aneurysm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699266/
https://www.ncbi.nlm.nih.gov/pubmed/34943866
http://dx.doi.org/10.3390/cells10123357
work_keys_str_mv AT dubisjoanna associationsofgenesforkillercellimmunoglobulinlikereceptorsandtheirhumanleukocyteantigenabcligandswithabdominalaorticaneurysm
AT niepiekłominiewskawanda associationsofgenesforkillercellimmunoglobulinlikereceptorsandtheirhumanleukocyteantigenabcligandswithabdominalaorticaneurysm
AT jedruchniewicznatalia associationsofgenesforkillercellimmunoglobulinlikereceptorsandtheirhumanleukocyteantigenabcligandswithabdominalaorticaneurysm
AT sobczynskimaciej associationsofgenesforkillercellimmunoglobulinlikereceptorsandtheirhumanleukocyteantigenabcligandswithabdominalaorticaneurysm
AT witkiewiczwojciech associationsofgenesforkillercellimmunoglobulinlikereceptorsandtheirhumanleukocyteantigenabcligandswithabdominalaorticaneurysm
AT zapotocznynorbert associationsofgenesforkillercellimmunoglobulinlikereceptorsandtheirhumanleukocyteantigenabcligandswithabdominalaorticaneurysm
AT kusnierczykpiotr associationsofgenesforkillercellimmunoglobulinlikereceptorsandtheirhumanleukocyteantigenabcligandswithabdominalaorticaneurysm