Cargando…

Pan-Genomic Sequencing Reveals Actionable CDKN2A/2B Deletions and Kataegis in Anaplastic Thyroid Carcinoma

SIMPLE SUMMARY: Anaplastic thyroid carcinoma (ATC) is a tumor with exceedingly high mortality rates, and current treatment options are very limited once the disease has spread beyond the thyroid gland. Most of what we know of ATCs from a genetic standpoint is based upon previous analyses in which li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stenman, Adam, Yang, Minjun, Paulsson, Johan O., Zedenius, Jan, Paulsson, Kajsa, Juhlin, C. Christofer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699293/ https://www.ncbi.nlm.nih.gov/pubmed/34944959 http://dx.doi.org/10.3390/cancers13246340

Ejemplares similares

Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma
por: Stenman, Adam, et al.
Publicado: (2021)

Papillary thyroid carcinoma with pleomorphic tumor giant cells in a pregnant woman – a case report
por: Paulsson, Johan O., et al.
Publicado: (2018)

Prognostic Utility of the Ki-67 Labeling Index in Follicular Thyroid Tumors: a 20-Year Experience from a Tertiary Thyroid Center
por: Hellgren, L. Samuel, et al.
Publicado: (2022)

TERT Promoter Mutated Follicular Thyroid Carcinomas Exhibit a Distinct microRNA Expressional Profile with Potential Implications for Tumor Progression
por: Paulsson, Johan O., et al.
Publicado: (2021)

Development of metastatic poorly differentiated thyroid cancer from a sub-centimeter papillary thyroid carcinoma in a young patient with a germline MET mutation – association or random chance?
por: Johansson, Klara, et al.
Publicado: (2021)

Global RNA Expression and DNA Methylation Patterns in Primary Anaplastic Thyroid Cancer
por: Ravi, Naveen, et al.
Publicado: (2020)

GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours
por: Paulsson, Johan O, et al.
Publicado: (2020)

TERT Immunohistochemistry Is a Poor Predictor of TERT Promoter Mutations and Gene Expression in Follicular Thyroid Carcinoma
por: Paulsson, Johan O., et al.
Publicado: (2018)

Clinical Routine TERT Promoter Mutational Screening of Follicular Thyroid Tumors of Uncertain Malignant Potential (FT-UMPs): A Useful Predictor of Metastatic Disease
por: Hysek, Martin, et al.
Publicado: (2019)

Novel Insights in the Genomics of Anaplastic Thyroid Carcinoma: A Role for Cyclin-Dependent Kinase Inhibition?
por: Stenman, Adam, et al.
Publicado: (2023)

Nuclear-specific accumulation of telomerase reverse transcriptase (TERT) mRNA in TERT promoter mutated follicular thyroid tumours visualised by in situ hybridisation: a possible clinical screening tool?
por: Hellgren, L Samuel, et al.
Publicado: (2022)

Papillary Thyroid Carcinoma with Desmoid-Like Fibromatosis: Double Trouble?
por: Juhlin, C. Christofer, et al.
Publicado: (2022)

Over-diagnosis of potential malignant behavior in MEN 2A-associated pheochromocytomas using the PASS and GAPP algorithms
por: Stenman, Adam, et al.
Publicado: (2018)

Synchronous lateral lymph node metastases from papillary and follicular thyroid carcinoma: case report and review of the literature
por: Stenman, Adam, et al.
Publicado: (2022)

Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8
por: Paulsson, Johan O, et al.
Publicado: (2021)

Identification of Targetable Lesions in Anaplastic Thyroid Cancer by Genome Profiling
por: Ravi, Naveen, et al.
Publicado: (2019)

The Value of Histological Algorithms to Predict the Malignancy Potential of Pheochromocytomas and Abdominal Paragangliomas—A Meta-Analysis and Systematic Review of the Literature
por: Stenman, Adam, et al.
Publicado: (2019)

Adrenal and periadrenal schwannoma: histological, molecular and clinical characterization of an institutional case series
por: Stenman, Adam, et al.
Publicado: (2023)

Transcription Factor Profiling Identifies Spatially Heterogenous Mediators of Follicular Thyroid Cancer Invasion
por: Nicolson, Norman G., et al.
Publicado: (2020)

Signet ring cell variant of follicular thyroid carcinoma: Report of two cases with focus on morphological, expressional and genetic characteristics
por: Hysek, Martin, et al.
Publicado: (2019)

Distinguishing between thyroid and parathyroid nodules by ultrasound: a potential game-changer in clinical practice?
por: Juhlin, C. Christofer, et al.
Publicado: (2023)

Synchronous aldosterone- and cortisol-producing adrenocortical adenomas diagnosed using CYP11B immunohistochemistry
por: Stenman, Adam, et al.
Publicado: (2019)

Single base substitution and insertion/deletion mutational signatures in adult core binding factor acute myeloid leukemia
por: Gunnarsson, Rebeqa, et al.
Publicado: (2022)

Aberrant DNA repair as a potential contributor for the clonal evolution in subsets of anaplastic thyroid carcinomas arising through dedifferentiation: implications for future therapeutic algorithms?
por: Juhlin, Carl Christofer
Publicado: (2020)

Metastatic-prone telomerase reverse transcriptase (TERT) promoter and v-Raf murine sarcoma viral oncogene homolog B (BRAF) mutated tall cell variant of papillary thyroid carcinoma arising in ectopic thyroid tissue: A case report
por: Stenman, Adam, et al.
Publicado: (2021)

Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2
por: Studd, James B., et al.
Publicado: (2017)

Author Correction: Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2
por: Studd, James B., et al.
Publicado: (2018)

Parathyroid Adenoma With Respiratory-Like Epithelium: Case Report of a Potential Mimic With Unknown Etiology
por: Juhlin, C. Christofer, et al.
Publicado: (2021)

Chromosome gains drive childhood ALL
por: Paulsson, Kajsa
Publicado: (2015)

The Clinical Significance of Lymph Node Ratio and Ki-67 Expression in Papillary Thyroid Cancer
por: Lindfors, Helene, et al.
Publicado: (2021)

AID/APOBEC cytosine deaminase induces genome-wide kataegis
por: Lada, Artem G, et al.
Publicado: (2012)

Macrofollicular Variant of Follicular Thyroid Carcinoma (MV-FTC) with a Somatic DICER1 Gene Mutation: Case Report and Review of the Literature
por: Hellgren, L. Samuel, et al.
Publicado: (2020)

Clinical Routine Application of the Second-generation Neuroendocrine Markers ISL1, INSM1, and Secretagogin in Neuroendocrine Neoplasia: Staining Outcomes and Potential Clues for Determining Tumor Origin
por: Juhlin, Carl Christofer, et al.
Publicado: (2020)

Metastatic malignant melanoma with neuroendocrine differentiation: a case report and review of the literature
por: Juhlin, Carl Christofer, et al.
Publicado: (2020)

Metastatic Neuroendocrine Neoplasms of Unknown Primary: Clues from Pathology Workup
por: Juhlin, Carl Christofer, et al.
Publicado: (2022)

Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A
por: Karrman, Kristina, et al.
Publicado: (2015)

TOP2A Expression in Pheochromocytoma and Abdominal Paraganglioma: a Marker of Poor Clinical Outcome?
por: Solhusløkk Höse, Karolina, et al.
Publicado: (2023)

5hmC Immunohistochemistry: A Predictor of TERT Promoter Mutational Status in Follicular Thyroid Carcinoma?
por: Hysek, Martin, et al.
Publicado: (2023)

Presentation, Treatment, Histology, and Outcomes in Adrenal Medullary Hyperplasia Compared With Pheochromocytoma
por: Falhammar, Henrik, et al.
Publicado: (2019)

Minimally invasive follicular thyroid carcinomas: prognostic factors
por: Stenson, Gustav, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6hlrd7agovrmg4bk1h8k2assa3