Cargando…

Modulation of Hippocampal Astroglial Activity by Synaptamide in Rats with Neuropathic Pain

The present study demonstrates that synaptamide (N-docosahexaenoylethanolamine), an endogenous metabolite of docosahexaenoic acid, when administered subcutaneously (4 mg/kg/day, 14 days), exhibits analgesic activity and promotes cognitive recovery in the rat sciatic nerve chronic constriction injury...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manzhulo, Igor, Manzhulo, Olga, Tyrtyshnaia, Anna, Ponomarenko, Arina, Konovalova, Sophia, Ermolenko, Ekaterina, Milkina, Elena, Starinets, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699312/ https://www.ncbi.nlm.nih.gov/pubmed/34942863 http://dx.doi.org/10.3390/brainsci11121561

Ejemplares similares

Synaptamide Modulates Astroglial Activity in Mild Traumatic Brain Injury
por: Ponomarenko, Arina, et al.
Publicado: (2022)

Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain
por: Tyrtyshnaia, Anna, et al.
Publicado: (2021)

Synaptamide Ameliorates Hippocampal Neurodegeneration and Glial Activation in Mice with Traumatic Brain Injury
por: Tyrtyshnaia, Anna, et al.
Publicado: (2023)

Anti-Inflammatory Activity of Synaptamide in the Peripheral Nervous System in a Model of Sciatic Nerve Injury
por: Starinets, Anna, et al.
Publicado: (2023)

Neuroinflammation and adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment in aged mice
por: Tyrtyshnaia, Anna, et al.
Publicado: (2019)

N-Docosahexaenoylethanolamine Attenuates Neuroinflammation and Improves Hippocampal Neurogenesis in Rats with Sciatic Nerve Chronic Constriction Injury
por: Tyrtyshnaia, Anna A., et al.
Publicado: (2020)

Fatty Acid-Derived N-acylethanolamines Dietary Supplementation Attenuates Neuroinflammation and Cognitive Impairment in LPS Murine Model
por: Tyrtyshnaia, Anna, et al.
Publicado: (2022)

Anti-Inflammatory Activity of N-Docosahexaenoylethanolamine and N-Eicosapentaenoylethanolamine in a Mouse Model of Lipopolysaccharide-Induced Neuroinflammation
por: Tyrtyshnaia, Anna, et al.
Publicado: (2021)

Neuropathic Pain Causes Memory Deficits and Dendrite Tree Morphology Changes in Mouse Hippocampus
por: Tyrtyshnaia, Anna, et al.
Publicado: (2020)

N-Docosahexanoylethanolamine Reduces Microglial Activation and Improves Hippocampal Plasticity in a Murine Model of Neuroinflammation
por: Tyrtyshnaia, Anna, et al.
Publicado: (2020)

N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats
por: Ponomarenko, Arina I., et al.
Publicado: (2021)

Effect of Oleoylethanolamide-Based Dietary Supplement on Systemic Inflammation in the Development of Alimentary-Induced Obesity in Mice
por: Ivashkevich, Darya, et al.
Publicado: (2023)

Cancer stem cells and microglia in the processes of glioblastoma multiforme invasive growth
por: Bryukhovetskiy, Igor, et al.
Publicado: (2016)

Acute neuroinflammation provokes intracellular acidification in mouse hippocampus
por: Tyrtyshnaia, Anna A., et al.
Publicado: (2016)

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding
por: Huang, Bill X., et al.
Publicado: (2020)

Treadmill Exercise Induces Hippocampal Astroglial Alterations in Rats
por: Bernardi, Caren, et al.
Publicado: (2013)

Astroglial Connexin 43 Regulates Synaptic Vesicle Release at Hippocampal Synapses
por: Cheung, Giselle, et al.
Publicado: (2023)

Atypical astroglial pTDP‐43 pathology in astroglial predominant tauopathy
por: Gelpi, Ellen, et al.
Publicado: (2021)

Astroglial Plasticity Is Implicated in Hippocampal Remodelling in Adult Rats Exposed to Antenatal Dexamethasone
por: Shende, Vishvesh H., et al.
Publicado: (2015)

Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures
por: Lim, Dmitry, et al.
Publicado: (2018)

Upregulation of astroglial connexin 30 impairs hippocampal synaptic activity and recognition memory
por: Hardy, Eléonore, et al.
Publicado: (2023)

Potentiation of Amitriptyline Anti-Hyperalgesic-Like Action By Astroglial Connexin 43 Inhibition in Neuropathic Rats
por: Jeanson, Tiffany, et al.
Publicado: (2016)

Tetracyclic 1,4-Naphthoquinone Thioglucoside Conjugate U-556 Blocks the Purinergic P2X7 Receptor in Macrophages and Exhibits Anti-Inflammatory Activity In Vivo
por: Kozlovskiy, Sergei, et al.
Publicado: (2023)

Interaction of hematopoietic CD34(+) CD45(+) stem cells and cancer cells stimulated by TGF-β1 in a model of glioblastoma in vitro
por: Milkina, Elena, et al.
Publicado: (2018)

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
por: Pannasch, Ulrike, et al.
Publicado: (2012)

Neuronal and Astroglial Correlates Underlying Spatiotemporal Intrinsic Optical Signal in the Rat Hippocampal Slice
por: Pál, Ildikó, et al.
Publicado: (2013)

Involvement of hippocampal acetylcholinergic receptors in electroacupuncture analgesia in neuropathic pain rats
por: Chen, Shu Ping, et al.
Publicado: (2016)

Physiology of Astroglial Excitability
por: Verkhratsky, Alexei, et al.
Publicado: (2020)

Astroglial Modulation of Hydromineral Balance and Cerebral Edema
por: Wang, Yu-Feng, et al.
Publicado: (2018)

Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic pain☆
por: Wang, Junying, et al.
Publicado: (2012)

Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling
por: Liu, Shenbin, et al.
Publicado: (2016)

Astroglial Induction of in vivo Angiogenesis
por: Suárez, I., et al.
Publicado: (1994)

Astroglial Connexins in Neurodegenerative Diseases
por: Huang, Xiaomin, et al.
Publicado: (2021)

NEUROPATHIC PAIN AND CHRONIC PAIN AS AN UNDERESTIMATED INTERDISCIPLINARY PROBLEM
por: Szewczyk, Anna K., et al.
Publicado: (2022)

Telomere Length Modulation in Human Astroglial Brain Tumors
por: La Torre, Domenico, et al.
Publicado: (2013)

Cucumarioside A(2)-2 Causes Macrophage Activation in Mouse Spleen
por: Pislyagin, Evgeny A., et al.
Publicado: (2017)

Neuropathic pain and cytokines: current perspectives
por: Clark, Anna K, et al.
Publicado: (2013)

Activation of hippocampal MEK1 contributes to the cumulative antinociceptive effect of electroacupuncture in neuropathic pain rats
por: Gao, Yong-Hui, et al.
Publicado: (2016)

The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation
por: Zhu, Chunyan, et al.
Publicado: (2018)

Astroglial networking contributes to neurometabolic coupling
por: Escartin, Carole, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_qraivmmppmq77dt6i6cj6odhv1