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Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset

Major depressive disorder (MDD) is a global healthcare issue and one of the leading causes of disability. Machine learning combined with non-invasive electroencephalography (EEG) has recently been shown to have the potential to diagnose MDD. However, most of these studies analyzed small samples of p...

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Autores principales: Wu, Chien-Te, Huang, Hao-Chuan, Huang, Shiuan, Chen, I-Ming, Liao, Shih-Cheng, Chen, Chih-Ken, Lin, Chemin, Lee, Shwu-Hua, Chen, Mu-Hong, Tsai, Chia-Fen, Weng, Chang-Hsin, Ko, Li-Wei, Jung, Tzyy-Ping, Liu, Yi-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699348/
https://www.ncbi.nlm.nih.gov/pubmed/34940256
http://dx.doi.org/10.3390/bios11120499
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author Wu, Chien-Te
Huang, Hao-Chuan
Huang, Shiuan
Chen, I-Ming
Liao, Shih-Cheng
Chen, Chih-Ken
Lin, Chemin
Lee, Shwu-Hua
Chen, Mu-Hong
Tsai, Chia-Fen
Weng, Chang-Hsin
Ko, Li-Wei
Jung, Tzyy-Ping
Liu, Yi-Hung
author_facet Wu, Chien-Te
Huang, Hao-Chuan
Huang, Shiuan
Chen, I-Ming
Liao, Shih-Cheng
Chen, Chih-Ken
Lin, Chemin
Lee, Shwu-Hua
Chen, Mu-Hong
Tsai, Chia-Fen
Weng, Chang-Hsin
Ko, Li-Wei
Jung, Tzyy-Ping
Liu, Yi-Hung
author_sort Wu, Chien-Te
collection PubMed
description Major depressive disorder (MDD) is a global healthcare issue and one of the leading causes of disability. Machine learning combined with non-invasive electroencephalography (EEG) has recently been shown to have the potential to diagnose MDD. However, most of these studies analyzed small samples of participants recruited from a single source, raising serious concerns about the generalizability of these results in clinical practice. Thus, it has become critical to re-evaluate the efficacy of various common EEG features for MDD detection across large and diverse datasets. To address this issue, we collected resting-state EEG data from 400 participants across four medical centers and tested classification performance of four common EEG features: band power (BP), coherence, Higuchi’s fractal dimension, and Katz’s fractal dimension. Then, a sequential backward selection (SBS) method was used to determine the optimal subset. To overcome the large data variability due to an increased data size and multi-site EEG recordings, we introduced the conformal kernel (CK) transformation to further improve the MDD as compared with the healthy control (HC) classification performance of support vector machine (SVM). The results show that (1) coherence features account for 98% of the optimal feature subset; (2) the CK-SVM outperforms other classifiers such as K-nearest neighbors (K-NN), linear discriminant analysis (LDA), and SVM; (3) the combination of the optimal feature subset and CK-SVM achieves a high five-fold cross-validation accuracy of 91.07% on the training set (140 MDD and 140 HC) and 84.16% on the independent test set (60 MDD and 60 HC). The current results suggest that the coherence-based connectivity is a more reliable feature for achieving high and generalizable MDD detection performance in real-life clinical practice.
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spelling pubmed-86993482021-12-24 Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset Wu, Chien-Te Huang, Hao-Chuan Huang, Shiuan Chen, I-Ming Liao, Shih-Cheng Chen, Chih-Ken Lin, Chemin Lee, Shwu-Hua Chen, Mu-Hong Tsai, Chia-Fen Weng, Chang-Hsin Ko, Li-Wei Jung, Tzyy-Ping Liu, Yi-Hung Biosensors (Basel) Article Major depressive disorder (MDD) is a global healthcare issue and one of the leading causes of disability. Machine learning combined with non-invasive electroencephalography (EEG) has recently been shown to have the potential to diagnose MDD. However, most of these studies analyzed small samples of participants recruited from a single source, raising serious concerns about the generalizability of these results in clinical practice. Thus, it has become critical to re-evaluate the efficacy of various common EEG features for MDD detection across large and diverse datasets. To address this issue, we collected resting-state EEG data from 400 participants across four medical centers and tested classification performance of four common EEG features: band power (BP), coherence, Higuchi’s fractal dimension, and Katz’s fractal dimension. Then, a sequential backward selection (SBS) method was used to determine the optimal subset. To overcome the large data variability due to an increased data size and multi-site EEG recordings, we introduced the conformal kernel (CK) transformation to further improve the MDD as compared with the healthy control (HC) classification performance of support vector machine (SVM). The results show that (1) coherence features account for 98% of the optimal feature subset; (2) the CK-SVM outperforms other classifiers such as K-nearest neighbors (K-NN), linear discriminant analysis (LDA), and SVM; (3) the combination of the optimal feature subset and CK-SVM achieves a high five-fold cross-validation accuracy of 91.07% on the training set (140 MDD and 140 HC) and 84.16% on the independent test set (60 MDD and 60 HC). The current results suggest that the coherence-based connectivity is a more reliable feature for achieving high and generalizable MDD detection performance in real-life clinical practice. MDPI 2021-12-06 /pmc/articles/PMC8699348/ /pubmed/34940256 http://dx.doi.org/10.3390/bios11120499 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Chien-Te
Huang, Hao-Chuan
Huang, Shiuan
Chen, I-Ming
Liao, Shih-Cheng
Chen, Chih-Ken
Lin, Chemin
Lee, Shwu-Hua
Chen, Mu-Hong
Tsai, Chia-Fen
Weng, Chang-Hsin
Ko, Li-Wei
Jung, Tzyy-Ping
Liu, Yi-Hung
Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset
title Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset
title_full Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset
title_fullStr Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset
title_full_unstemmed Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset
title_short Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset
title_sort resting-state eeg signal for major depressive disorder detection: a systematic validation on a large and diverse dataset
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699348/
https://www.ncbi.nlm.nih.gov/pubmed/34940256
http://dx.doi.org/10.3390/bios11120499
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