CRISPR-to-Kill (C2K)–Employing the Bacterial Immune System to Kill Cancer Cells

SIMPLE SUMMARY: Reasoning that multiple DNA breaks will trigger programmed cell death, we generated lentiviral CRISPR-to-kill (C2K) vectors targeting highly repetitive SINE sequences for cancer gene therapy. In proof-of-concept experiments, C2K-Alu-vectors selectively killed human, but not murine ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Głów, Dawid, Maire, Cecile L., Schwarze, Lea Isabell, Lamszus, Katrin, Fehse, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699370/
https://www.ncbi.nlm.nih.gov/pubmed/34944926
http://dx.doi.org/10.3390/cancers13246306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699370/
https://www.ncbi.nlm.nih.gov/pubmed/34944926
http://dx.doi.org/10.3390/cancers13246306

Ejemplares similares