A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma

Li Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome caused by germline mutations in TP53. TP53 is the most common mutated gene in human cancer, occurring in 30–50% of glioblastomas (GBM). Here, we highlight a precision medicine platform to identify potential targets for a GBM p...

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Detalles Bibliográficos
Autores principales: Reed, Megan R., Lyle, A. Geoffrey, De Loose, Annick, Maddukuri, Leena, Learned, Katrina, Beale, Holly C., Kephart, Ellen T., Cheney, Allison, van den Bout, Anouk, Lee, Madison P., Hundley, Kelsey N., Smith, Ashley M., DesRochers, Teresa M., Vibat, Cecile Rose T., Gokden, Murat, Salama, Sofie, Wardell, Christopher P., Eoff, Robert L., Vaske, Olena M., Rodriguez, Analiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699481/
https://www.ncbi.nlm.nih.gov/pubmed/34943910
http://dx.doi.org/10.3390/cells10123400

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