Gut Metabolite Trimethylamine N-Oxide Protects INS-1 β-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions

Serum accumulation of the gut microbial metabolite trimethylamine N-oxide (TMAO) is associated with high caloric intake and type 2 diabetes (T2D). Impaired pancreatic β-cell function is a hallmark of diet-induced T2D, which is linked to hyperglycemia and hyperlipidemia. While TMAO production via the...

Descripción completa

Detalles Bibliográficos
Autores principales: Krueger, Emily S., Beales, Joseph L., Russon, Kacie B., Elison, Weston S., Davis, Jordan R., Hansen, Jackson M., Neilson, Andrew P., Hansen, Jason M., Tessem, Jeffery S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699500/
https://www.ncbi.nlm.nih.gov/pubmed/34944536
http://dx.doi.org/10.3390/biom11121892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699500/
https://www.ncbi.nlm.nih.gov/pubmed/34944536
http://dx.doi.org/10.3390/biom11121892

Ejemplares similares