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Gut Metabolite Trimethylamine N-Oxide Protects INS-1 β-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions
Serum accumulation of the gut microbial metabolite trimethylamine N-oxide (TMAO) is associated with high caloric intake and type 2 diabetes (T2D). Impaired pancreatic β-cell function is a hallmark of diet-induced T2D, which is linked to hyperglycemia and hyperlipidemia. While TMAO production via the...
Autores principales: | Krueger, Emily S., Beales, Joseph L., Russon, Kacie B., Elison, Weston S., Davis, Jordan R., Hansen, Jackson M., Neilson, Andrew P., Hansen, Jason M., Tessem, Jeffery S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699500/ https://www.ncbi.nlm.nih.gov/pubmed/34944536 http://dx.doi.org/10.3390/biom11121892 |
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