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Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study
Background: The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI). Methods: Retrospective observational study including adult (>18 years)...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699519/ https://www.ncbi.nlm.nih.gov/pubmed/34942959 http://dx.doi.org/10.3390/brainsci11121657 |
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author | Luz Teixeira, Thomas Peluso, Lorenzo Banco, Pierluigi Njimi, Hassane Abi-Khalil, Layal Chanchay Pillajo, Mélanie Schuind, Sophie Creteur, Jacques Bouzat, Pierre Taccone, Fabio Silvio |
author_facet | Luz Teixeira, Thomas Peluso, Lorenzo Banco, Pierluigi Njimi, Hassane Abi-Khalil, Layal Chanchay Pillajo, Mélanie Schuind, Sophie Creteur, Jacques Bouzat, Pierre Taccone, Fabio Silvio |
author_sort | Luz Teixeira, Thomas |
collection | PubMed |
description | Background: The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI). Methods: Retrospective observational study including adult (>18 years) TBI patients admitted from January 2018 to December 2020, with available NPi on admission. Abnormal NPi was considered if <3. Unfavorable neurological outcome (UO) at hospital discharge was considered for a Glasgow Outcome Scale of 1–3. Results: 100 patients were included over the study period (median age 48 (34–69) years and median GCS on admission 11 (6–15)); 49 (49%) patients had UO. On admission, 20 (20%) patients had an abnormal NPi (NPi < 3); median worst (i.e., from both eyes) NPi was 4.2 (3.2–4.5). Median worst and mean NPi on admission were significantly lower in the UO group than others (3.9 (1.7–4.4) vs. 4.4 (3.7–4.6); p = 0.005–4.0 (2.6–4.5) vs. 4.5 (3.9–4.7); p = 0.002, respectively). The ROC curve for the worst and mean NPi showed a moderate accuracy to predict UO (AUC 0.66 (0.56–0.77); p = 0.005 and 0.68 (0.57–0.78); p = 0.002). However, in a generalized linear model, the prognostic role of NPi on admission was limited. Conclusions: Low NPi on admission has limited prognostic value in TBI. |
format | Online Article Text |
id | pubmed-8699519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86995192021-12-24 Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study Luz Teixeira, Thomas Peluso, Lorenzo Banco, Pierluigi Njimi, Hassane Abi-Khalil, Layal Chanchay Pillajo, Mélanie Schuind, Sophie Creteur, Jacques Bouzat, Pierre Taccone, Fabio Silvio Brain Sci Article Background: The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI). Methods: Retrospective observational study including adult (>18 years) TBI patients admitted from January 2018 to December 2020, with available NPi on admission. Abnormal NPi was considered if <3. Unfavorable neurological outcome (UO) at hospital discharge was considered for a Glasgow Outcome Scale of 1–3. Results: 100 patients were included over the study period (median age 48 (34–69) years and median GCS on admission 11 (6–15)); 49 (49%) patients had UO. On admission, 20 (20%) patients had an abnormal NPi (NPi < 3); median worst (i.e., from both eyes) NPi was 4.2 (3.2–4.5). Median worst and mean NPi on admission were significantly lower in the UO group than others (3.9 (1.7–4.4) vs. 4.4 (3.7–4.6); p = 0.005–4.0 (2.6–4.5) vs. 4.5 (3.9–4.7); p = 0.002, respectively). The ROC curve for the worst and mean NPi showed a moderate accuracy to predict UO (AUC 0.66 (0.56–0.77); p = 0.005 and 0.68 (0.57–0.78); p = 0.002). However, in a generalized linear model, the prognostic role of NPi on admission was limited. Conclusions: Low NPi on admission has limited prognostic value in TBI. MDPI 2021-12-20 /pmc/articles/PMC8699519/ /pubmed/34942959 http://dx.doi.org/10.3390/brainsci11121657 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Luz Teixeira, Thomas Peluso, Lorenzo Banco, Pierluigi Njimi, Hassane Abi-Khalil, Layal Chanchay Pillajo, Mélanie Schuind, Sophie Creteur, Jacques Bouzat, Pierre Taccone, Fabio Silvio Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study |
title | Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study |
title_full | Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study |
title_fullStr | Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study |
title_full_unstemmed | Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study |
title_short | Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study |
title_sort | early pupillometry assessment in traumatic brain injury patients: a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699519/ https://www.ncbi.nlm.nih.gov/pubmed/34942959 http://dx.doi.org/10.3390/brainsci11121657 |
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