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Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study

Background: The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI). Methods: Retrospective observational study including adult (>18 years)...

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Autores principales: Luz Teixeira, Thomas, Peluso, Lorenzo, Banco, Pierluigi, Njimi, Hassane, Abi-Khalil, Layal, Chanchay Pillajo, Mélanie, Schuind, Sophie, Creteur, Jacques, Bouzat, Pierre, Taccone, Fabio Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699519/
https://www.ncbi.nlm.nih.gov/pubmed/34942959
http://dx.doi.org/10.3390/brainsci11121657
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author Luz Teixeira, Thomas
Peluso, Lorenzo
Banco, Pierluigi
Njimi, Hassane
Abi-Khalil, Layal
Chanchay Pillajo, Mélanie
Schuind, Sophie
Creteur, Jacques
Bouzat, Pierre
Taccone, Fabio Silvio
author_facet Luz Teixeira, Thomas
Peluso, Lorenzo
Banco, Pierluigi
Njimi, Hassane
Abi-Khalil, Layal
Chanchay Pillajo, Mélanie
Schuind, Sophie
Creteur, Jacques
Bouzat, Pierre
Taccone, Fabio Silvio
author_sort Luz Teixeira, Thomas
collection PubMed
description Background: The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI). Methods: Retrospective observational study including adult (>18 years) TBI patients admitted from January 2018 to December 2020, with available NPi on admission. Abnormal NPi was considered if <3. Unfavorable neurological outcome (UO) at hospital discharge was considered for a Glasgow Outcome Scale of 1–3. Results: 100 patients were included over the study period (median age 48 (34–69) years and median GCS on admission 11 (6–15)); 49 (49%) patients had UO. On admission, 20 (20%) patients had an abnormal NPi (NPi < 3); median worst (i.e., from both eyes) NPi was 4.2 (3.2–4.5). Median worst and mean NPi on admission were significantly lower in the UO group than others (3.9 (1.7–4.4) vs. 4.4 (3.7–4.6); p = 0.005–4.0 (2.6–4.5) vs. 4.5 (3.9–4.7); p = 0.002, respectively). The ROC curve for the worst and mean NPi showed a moderate accuracy to predict UO (AUC 0.66 (0.56–0.77); p = 0.005 and 0.68 (0.57–0.78); p = 0.002). However, in a generalized linear model, the prognostic role of NPi on admission was limited. Conclusions: Low NPi on admission has limited prognostic value in TBI.
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spelling pubmed-86995192021-12-24 Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study Luz Teixeira, Thomas Peluso, Lorenzo Banco, Pierluigi Njimi, Hassane Abi-Khalil, Layal Chanchay Pillajo, Mélanie Schuind, Sophie Creteur, Jacques Bouzat, Pierre Taccone, Fabio Silvio Brain Sci Article Background: The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI). Methods: Retrospective observational study including adult (>18 years) TBI patients admitted from January 2018 to December 2020, with available NPi on admission. Abnormal NPi was considered if <3. Unfavorable neurological outcome (UO) at hospital discharge was considered for a Glasgow Outcome Scale of 1–3. Results: 100 patients were included over the study period (median age 48 (34–69) years and median GCS on admission 11 (6–15)); 49 (49%) patients had UO. On admission, 20 (20%) patients had an abnormal NPi (NPi < 3); median worst (i.e., from both eyes) NPi was 4.2 (3.2–4.5). Median worst and mean NPi on admission were significantly lower in the UO group than others (3.9 (1.7–4.4) vs. 4.4 (3.7–4.6); p = 0.005–4.0 (2.6–4.5) vs. 4.5 (3.9–4.7); p = 0.002, respectively). The ROC curve for the worst and mean NPi showed a moderate accuracy to predict UO (AUC 0.66 (0.56–0.77); p = 0.005 and 0.68 (0.57–0.78); p = 0.002). However, in a generalized linear model, the prognostic role of NPi on admission was limited. Conclusions: Low NPi on admission has limited prognostic value in TBI. MDPI 2021-12-20 /pmc/articles/PMC8699519/ /pubmed/34942959 http://dx.doi.org/10.3390/brainsci11121657 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luz Teixeira, Thomas
Peluso, Lorenzo
Banco, Pierluigi
Njimi, Hassane
Abi-Khalil, Layal
Chanchay Pillajo, Mélanie
Schuind, Sophie
Creteur, Jacques
Bouzat, Pierre
Taccone, Fabio Silvio
Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study
title Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study
title_full Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study
title_fullStr Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study
title_full_unstemmed Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study
title_short Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study
title_sort early pupillometry assessment in traumatic brain injury patients: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699519/
https://www.ncbi.nlm.nih.gov/pubmed/34942959
http://dx.doi.org/10.3390/brainsci11121657
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