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Age Related Differences in Monocyte Subsets and Cytokine Pattern during Acute COVID-19—A Prospective Observational Longitudinal Study

The COVID-19 pandemic drastically highlighted the vulnerability of the elderly population towards viral and other infectious threats, illustrating that aging is accompanied by dysregulated immune responses currently summarized in terms like inflammaging and immunoparalysis. To gain a better understa...

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Autores principales: Pirabe, Anita, Heber, Stefan, Schrottmaier, Waltraud C., Schmuckenschlager, Anna, Treiber, Sonja, Pereyra, David, Santol, Jonas, Pawelka, Erich, Traugott, Marianna, Schörgenhofer, Christian, Seitz, Tamara, Karolyi, Mario, Jilma, Bernd, Resch, Ulrike, Zoufaly, Alexander, Assinger, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699549/
https://www.ncbi.nlm.nih.gov/pubmed/34943881
http://dx.doi.org/10.3390/cells10123373
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author Pirabe, Anita
Heber, Stefan
Schrottmaier, Waltraud C.
Schmuckenschlager, Anna
Treiber, Sonja
Pereyra, David
Santol, Jonas
Pawelka, Erich
Traugott, Marianna
Schörgenhofer, Christian
Seitz, Tamara
Karolyi, Mario
Jilma, Bernd
Resch, Ulrike
Zoufaly, Alexander
Assinger, Alice
author_facet Pirabe, Anita
Heber, Stefan
Schrottmaier, Waltraud C.
Schmuckenschlager, Anna
Treiber, Sonja
Pereyra, David
Santol, Jonas
Pawelka, Erich
Traugott, Marianna
Schörgenhofer, Christian
Seitz, Tamara
Karolyi, Mario
Jilma, Bernd
Resch, Ulrike
Zoufaly, Alexander
Assinger, Alice
author_sort Pirabe, Anita
collection PubMed
description The COVID-19 pandemic drastically highlighted the vulnerability of the elderly population towards viral and other infectious threats, illustrating that aging is accompanied by dysregulated immune responses currently summarized in terms like inflammaging and immunoparalysis. To gain a better understanding on the underlying mechanisms of the age-associated risk of adverse outcome in individuals experiencing a SARS-CoV-2 infection, we analyzed the impact of age on circulating monocyte phenotypes, activation markers and inflammatory cytokines including interleukin 6 (IL-6), IL-8 and tumor necrosis factor (TNF) in the context of COVID-19 disease progression and outcome in 110 patients. Our data indicate no age-associated differences in peripheral monocyte counts or subset composition. However, age and outcome are associated with differences in monocyte activation status. Moreover, a distinct cytokine pattern of IL-6, IL-8 and TNF in elderly survivors versus non-survivors, which consolidates over the time of hospitalization, suggests that older patients with adverse outcomes experience an inappropriate immune response, reminiscent of an inflammaging driven immunoparalysis. Our study underscores the value, necessity and importance of longitudinal monitoring in elderly COVID-19 patients, as dynamic changes after symptom onset can be observed, which allow for a differentiated insight into confounding factors that impact the complex pathogenesis following an infection with SARS-CoV-2.
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spelling pubmed-86995492021-12-24 Age Related Differences in Monocyte Subsets and Cytokine Pattern during Acute COVID-19—A Prospective Observational Longitudinal Study Pirabe, Anita Heber, Stefan Schrottmaier, Waltraud C. Schmuckenschlager, Anna Treiber, Sonja Pereyra, David Santol, Jonas Pawelka, Erich Traugott, Marianna Schörgenhofer, Christian Seitz, Tamara Karolyi, Mario Jilma, Bernd Resch, Ulrike Zoufaly, Alexander Assinger, Alice Cells Article The COVID-19 pandemic drastically highlighted the vulnerability of the elderly population towards viral and other infectious threats, illustrating that aging is accompanied by dysregulated immune responses currently summarized in terms like inflammaging and immunoparalysis. To gain a better understanding on the underlying mechanisms of the age-associated risk of adverse outcome in individuals experiencing a SARS-CoV-2 infection, we analyzed the impact of age on circulating monocyte phenotypes, activation markers and inflammatory cytokines including interleukin 6 (IL-6), IL-8 and tumor necrosis factor (TNF) in the context of COVID-19 disease progression and outcome in 110 patients. Our data indicate no age-associated differences in peripheral monocyte counts or subset composition. However, age and outcome are associated with differences in monocyte activation status. Moreover, a distinct cytokine pattern of IL-6, IL-8 and TNF in elderly survivors versus non-survivors, which consolidates over the time of hospitalization, suggests that older patients with adverse outcomes experience an inappropriate immune response, reminiscent of an inflammaging driven immunoparalysis. Our study underscores the value, necessity and importance of longitudinal monitoring in elderly COVID-19 patients, as dynamic changes after symptom onset can be observed, which allow for a differentiated insight into confounding factors that impact the complex pathogenesis following an infection with SARS-CoV-2. MDPI 2021-11-30 /pmc/articles/PMC8699549/ /pubmed/34943881 http://dx.doi.org/10.3390/cells10123373 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pirabe, Anita
Heber, Stefan
Schrottmaier, Waltraud C.
Schmuckenschlager, Anna
Treiber, Sonja
Pereyra, David
Santol, Jonas
Pawelka, Erich
Traugott, Marianna
Schörgenhofer, Christian
Seitz, Tamara
Karolyi, Mario
Jilma, Bernd
Resch, Ulrike
Zoufaly, Alexander
Assinger, Alice
Age Related Differences in Monocyte Subsets and Cytokine Pattern during Acute COVID-19—A Prospective Observational Longitudinal Study
title Age Related Differences in Monocyte Subsets and Cytokine Pattern during Acute COVID-19—A Prospective Observational Longitudinal Study
title_full Age Related Differences in Monocyte Subsets and Cytokine Pattern during Acute COVID-19—A Prospective Observational Longitudinal Study
title_fullStr Age Related Differences in Monocyte Subsets and Cytokine Pattern during Acute COVID-19—A Prospective Observational Longitudinal Study
title_full_unstemmed Age Related Differences in Monocyte Subsets and Cytokine Pattern during Acute COVID-19—A Prospective Observational Longitudinal Study
title_short Age Related Differences in Monocyte Subsets and Cytokine Pattern during Acute COVID-19—A Prospective Observational Longitudinal Study
title_sort age related differences in monocyte subsets and cytokine pattern during acute covid-19—a prospective observational longitudinal study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699549/
https://www.ncbi.nlm.nih.gov/pubmed/34943881
http://dx.doi.org/10.3390/cells10123373
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