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Activation of the alpha 7 nicotinic acetylcholine receptor mitigates osteoarthritis progression by inhibiting NF-κB/NLRP3 inflammasome activation and enhancing autophagy

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage degradation. Alpha 7 nicotinic acetylcholine receptor (α7nAChR) is associated with inflammatory and metabolic responses in OA. However, the mechanisms underlying the pathological process of OA remain unclear. The...

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Detalles Bibliográficos
Autores principales:	Zhu, Xianjie, Dai, Shiyou, Xia, Baohua, Gong, Jianbao, Ma, Bingzheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699641/ https://www.ncbi.nlm.nih.gov/pubmed/34941874 http://dx.doi.org/10.1371/journal.pone.0256507

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