NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells

Chronic hypoxia increases the resistance of pulmonary arteries by stimulating their contraction and augmenting their coverage by smooth muscle cells (SMCs). While these responses require adjustment of the vascular SMC transcriptome, regulatory elements are not well defined in this context. Here, we...

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Detalles Bibliográficos
Autores principales: Laban, Hebatullah, Siegmund, Sophia, Zappe, Maren, Trogisch, Felix A., Heineke, Jörg, Torre, Carolina De La, Fisslthaler, Beate, Arnold, Caroline, Lauryn, Jonathan, Büttner, Michael, Mogler, Carolin, Kato, Katsuhiro, Adams, Ralf H., Kuk, Hanna, Fischer, Andreas, Hecker, Markus, Kuebler, Wolfgang M., Korff, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699676/
https://www.ncbi.nlm.nih.gov/pubmed/34943801
http://dx.doi.org/10.3390/cells10123293

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