A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation

Endoplasmic reticulum–associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis. Although multiple ERAD pathways exist for targeting topologically distinct substrates, all pathways require substrate ubiquitination. Here, we characterize a ke...

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Detalles Bibliográficos
Autores principales: Smith, Christopher E., Tsai, Yien Che, Liang, Yu-He, Khago, Domarin, Mariano, Jennifer, Li, Jess, Tarasov, Sergey G., Gergel, Emma, Tsai, Borong, Villaneuva, Matthew, Clapp, Michelle E., Magidson, Valentin, Chari, Raj, Byrd, R. Andrew, Ji, Xinhua, Weissman, Allan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699718/
https://www.ncbi.nlm.nih.gov/pubmed/34879065
http://dx.doi.org/10.1371/journal.pbio.3001474

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