Bilateral and Optimistic Warning Paradigms Improve the Predictive Power of Intraoperative Facial Motor Evoked Potentials during Vestibular Schwannoma Surgery

SIMPLE SUMMARY: During surgery for vestibular schwannomas, the facial nerve is monitored via motor evoked potentials (facial nerve MEP). The established warning criteria for facial nerve MEP signal changes mostly refer to the ipsilateral side and disregard the contralateral side. Furthermore, the surgeon is warned as soon as the signal of a single facial muscle deteriorates. We examined how the predictive power of the facial nerve MEP would change if we used the percent change in ipsilateral versus contralateral MEP stimulation intensity over time as warning criterion; additionally, if we warned in a novel optimistic manner, a manner in which the surgeon would be warned only if all derived facial muscles deteriorate significantly, as opposed to the traditional method, in which the surgeon is warned as soon as a single muscle deteriorates. We retrospectively compared this approach to actual intraoperative warnings (based on unilateral threshold change, A-trains, and MEP loss) and show that with our method, the facial nerve MEP was significantly more specific and triggered fewer unnecessary warnings. ABSTRACT: Facial muscle corticobulbar motor evoked potentials (FMcoMEPs) are used to monitor facial nerve integrity during vestibular schwannoma resections to increase maximal safe tumor resection. Established warning criteria, based on ipsilateral amplitude reduction, have the limitation that the rate of false positive alarms is high, in part because FMcoMEP changes occur on both sides, e.g., due to brain shift or pneumocephalus. We retrospectively compared the predictive value of ipsilateral-only warning criteria and actual intraoperative warnings with a novel candidate warning criterion, based on “ipsilateral versus contralateral difference in relative stimulation threshold increase, from baseline to end of resection” (BilatMT ≥ 20%), combined with an optimistic approach in which a warning would be triggered only if all facial muscles on the affected side deteriorated. We included 60 patients who underwent resection of vestibular schwannoma. The outcome variable was postoperative facial muscle function. Retrospectively applying BilatMT, with the optimistic approach, was found to have a significantly better false positive rate, which was much lower (9% at day 90) than the traditionally used ipsilateral warning criteria (>20%) and was also lower than actual intraoperative warnings. This is the first report combining the threshold method with an optimistic approach in a bilateral multi-facial muscle setup. This method could substantially reduce the rate of false positive alarms in FMcoMEP monitoring.