Meningeal Lymphatics: An Immune Gateway for the Central Nervous System

The recent (re)discovery of the meningeal lymphatic system has opened new theories as to how immune cells traffic and interact with the central nervous system (CNS). While evidence is accumulating on the contribution of the meningeal lymphatic system in both homeostatic and disease conditions, a lot...

Descripción completa

Detalles Bibliográficos
Autores principales: Tavares, Gabriel A., Louveau, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699870/
https://www.ncbi.nlm.nih.gov/pubmed/34943894
http://dx.doi.org/10.3390/cells10123385
_version_ 1784620618432380928
author Tavares, Gabriel A.
Louveau, Antoine
author_facet Tavares, Gabriel A.
Louveau, Antoine
author_sort Tavares, Gabriel A.
collection PubMed
description The recent (re)discovery of the meningeal lymphatic system has opened new theories as to how immune cells traffic and interact with the central nervous system (CNS). While evidence is accumulating on the contribution of the meningeal lymphatic system in both homeostatic and disease conditions, a lot remains unknown about the mechanisms that allow for interaction between the meningeal lymphatic system and immune cells. In this review, we synthesize the knowledge about the lymphatic immune interaction in the CNS and highlight the important questions that remain to be answered.
format Online
Article
Text
id pubmed-8699870
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86998702021-12-24 Meningeal Lymphatics: An Immune Gateway for the Central Nervous System Tavares, Gabriel A. Louveau, Antoine Cells Review The recent (re)discovery of the meningeal lymphatic system has opened new theories as to how immune cells traffic and interact with the central nervous system (CNS). While evidence is accumulating on the contribution of the meningeal lymphatic system in both homeostatic and disease conditions, a lot remains unknown about the mechanisms that allow for interaction between the meningeal lymphatic system and immune cells. In this review, we synthesize the knowledge about the lymphatic immune interaction in the CNS and highlight the important questions that remain to be answered. MDPI 2021-12-01 /pmc/articles/PMC8699870/ /pubmed/34943894 http://dx.doi.org/10.3390/cells10123385 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tavares, Gabriel A.
Louveau, Antoine
Meningeal Lymphatics: An Immune Gateway for the Central Nervous System
title Meningeal Lymphatics: An Immune Gateway for the Central Nervous System
title_full Meningeal Lymphatics: An Immune Gateway for the Central Nervous System
title_fullStr Meningeal Lymphatics: An Immune Gateway for the Central Nervous System
title_full_unstemmed Meningeal Lymphatics: An Immune Gateway for the Central Nervous System
title_short Meningeal Lymphatics: An Immune Gateway for the Central Nervous System
title_sort meningeal lymphatics: an immune gateway for the central nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699870/
https://www.ncbi.nlm.nih.gov/pubmed/34943894
http://dx.doi.org/10.3390/cells10123385
work_keys_str_mv AT tavaresgabriela meningeallymphaticsanimmunegatewayforthecentralnervoussystem
AT louveauantoine meningeallymphaticsanimmunegatewayforthecentralnervoussystem

Ejemplares similares