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LIM Kinases in Osteosarcoma Development

Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research and clinical advances during the past decades...

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Autores principales: Brion, Régis, Regnier, Laura, Mullard, Mathilde, Amiaud, Jérome, Rédini, Françoise, Verrecchia, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699892/
https://www.ncbi.nlm.nih.gov/pubmed/34944050
http://dx.doi.org/10.3390/cells10123542
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author Brion, Régis
Regnier, Laura
Mullard, Mathilde
Amiaud, Jérome
Rédini, Françoise
Verrecchia, Franck
author_facet Brion, Régis
Regnier, Laura
Mullard, Mathilde
Amiaud, Jérome
Rédini, Françoise
Verrecchia, Franck
author_sort Brion, Régis
collection PubMed
description Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research and clinical advances during the past decades, bone cancers remain a leading cause of death worldwide among paediatric cancer patients. Osteosarcomas are the most common malignant bone tumours in children and adolescents. Notwithstanding advances in therapeutic treatments, many patients succumb to these diseases. In particular, less than 30% of patients who demonstrate metastases at diagnosis or are poor responders to chemotherapy survive 5 years after initial diagnosis. LIM kinases (LIMKs), comprising LIMK1 and LIMK2, are common downstream effectors of several signalization pathways, and function as a signalling node that controls cytoskeleton dynamics through the phosphorylation of the cofilin family proteins. In recent decades, several reports have indicated that the functions of LIMKs are mainly implicated in the regulation of actin microfilament and the control of microtubule dynamics. Previous studies have thus identified LIMKs as cancer-promoting regulators in multiple organ cancers, such as breast cancer or prostate cancer. This review updates the current understanding of LIMK involvement in osteosarcoma progression.
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spelling pubmed-86998922021-12-24 LIM Kinases in Osteosarcoma Development Brion, Régis Regnier, Laura Mullard, Mathilde Amiaud, Jérome Rédini, Françoise Verrecchia, Franck Cells Review Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research and clinical advances during the past decades, bone cancers remain a leading cause of death worldwide among paediatric cancer patients. Osteosarcomas are the most common malignant bone tumours in children and adolescents. Notwithstanding advances in therapeutic treatments, many patients succumb to these diseases. In particular, less than 30% of patients who demonstrate metastases at diagnosis or are poor responders to chemotherapy survive 5 years after initial diagnosis. LIM kinases (LIMKs), comprising LIMK1 and LIMK2, are common downstream effectors of several signalization pathways, and function as a signalling node that controls cytoskeleton dynamics through the phosphorylation of the cofilin family proteins. In recent decades, several reports have indicated that the functions of LIMKs are mainly implicated in the regulation of actin microfilament and the control of microtubule dynamics. Previous studies have thus identified LIMKs as cancer-promoting regulators in multiple organ cancers, such as breast cancer or prostate cancer. This review updates the current understanding of LIMK involvement in osteosarcoma progression. MDPI 2021-12-15 /pmc/articles/PMC8699892/ /pubmed/34944050 http://dx.doi.org/10.3390/cells10123542 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Brion, Régis
Regnier, Laura
Mullard, Mathilde
Amiaud, Jérome
Rédini, Françoise
Verrecchia, Franck
LIM Kinases in Osteosarcoma Development
title LIM Kinases in Osteosarcoma Development
title_full LIM Kinases in Osteosarcoma Development
title_fullStr LIM Kinases in Osteosarcoma Development
title_full_unstemmed LIM Kinases in Osteosarcoma Development
title_short LIM Kinases in Osteosarcoma Development
title_sort lim kinases in osteosarcoma development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699892/
https://www.ncbi.nlm.nih.gov/pubmed/34944050
http://dx.doi.org/10.3390/cells10123542
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