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Phosphoproteomics Sample Preparation Impacts Biological Interpretation of Phosphorylation Signaling Outcomes

The influence of phosphoproteomics sample preparation methods on the biological interpretation of signaling outcome is unclear. Here, we demonstrate a strong bias in phosphorylation signaling targets uncovered by comparing the phosphoproteomes generated by two commonly used methods—strong cation exc...

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Detalles Bibliográficos
Autores principales: Sampadi, Bharath, Mullenders, Leon H. F., Vrieling, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699897/
https://www.ncbi.nlm.nih.gov/pubmed/34943915
http://dx.doi.org/10.3390/cells10123407