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Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes
There are several methods to assess the function of the autonomic nervous system. Among them, heart rate recovery (HRR) is an accepted, easy, low-cost technique. Different pathological conditions have been related to the development of autonomic dysfunction. Our study aimed to evaluate the relations...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699903/ https://www.ncbi.nlm.nih.gov/pubmed/34943423 http://dx.doi.org/10.3390/diagnostics11122187 |
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author | Aztatzi-Aguilar, O. Gamaliel Vargas-Domínguez, Claudia Debray-Garcia, Yazmin Ortega-Romero, Manolo S. Almeda-Valdés, Paloma Aguilar-Salinas, Carlos A. Naranjo-Meneses, M. Augusta Mena-Orozco, D. Abril Lam-Chung, César E. Cruz-Bautista, Ivette Sierra-Vargas, M. Patricia |
author_facet | Aztatzi-Aguilar, O. Gamaliel Vargas-Domínguez, Claudia Debray-Garcia, Yazmin Ortega-Romero, Manolo S. Almeda-Valdés, Paloma Aguilar-Salinas, Carlos A. Naranjo-Meneses, M. Augusta Mena-Orozco, D. Abril Lam-Chung, César E. Cruz-Bautista, Ivette Sierra-Vargas, M. Patricia |
author_sort | Aztatzi-Aguilar, O. Gamaliel |
collection | PubMed |
description | There are several methods to assess the function of the autonomic nervous system. Among them, heart rate recovery (HRR) is an accepted, easy, low-cost technique. Different pathological conditions have been related to the development of autonomic dysfunction. Our study aimed to evaluate the relationship between HRR and HRR-derived parameters in ambulatory patients with asthma or type 2 diabetes followed at the National Institutes of Health in Mexico City. A total of 78 participants, 50 women and, 28 men were enrolled; anthropometric, respiratory evaluations, and fasting blood samples were taken before participants performed a 6-min walking test (6MWT). Abnormal HRR was defined as a drop of ≤8 and ≤11 beats/min at 1 or 2 min and correlated negatively with basal oxygen saturation at 1 min. Heart rate at 1 min, correlated negatively with final oxygen saturation (p < 0.01). Statistically significant negative correlations were also observed between red cell count and white blood cell count and HOMA-IR with a p < 0.01. Since discrete hematological but significant changes correlated with HRR and HRR-derived parameters, we consider that these measures are helpful in clinical settings to identify subclinical autonomic dysfunction that permits us to prevent or anticipate chronic and fatal clinical outcomes. |
format | Online Article Text |
id | pubmed-8699903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86999032021-12-24 Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes Aztatzi-Aguilar, O. Gamaliel Vargas-Domínguez, Claudia Debray-Garcia, Yazmin Ortega-Romero, Manolo S. Almeda-Valdés, Paloma Aguilar-Salinas, Carlos A. Naranjo-Meneses, M. Augusta Mena-Orozco, D. Abril Lam-Chung, César E. Cruz-Bautista, Ivette Sierra-Vargas, M. Patricia Diagnostics (Basel) Article There are several methods to assess the function of the autonomic nervous system. Among them, heart rate recovery (HRR) is an accepted, easy, low-cost technique. Different pathological conditions have been related to the development of autonomic dysfunction. Our study aimed to evaluate the relationship between HRR and HRR-derived parameters in ambulatory patients with asthma or type 2 diabetes followed at the National Institutes of Health in Mexico City. A total of 78 participants, 50 women and, 28 men were enrolled; anthropometric, respiratory evaluations, and fasting blood samples were taken before participants performed a 6-min walking test (6MWT). Abnormal HRR was defined as a drop of ≤8 and ≤11 beats/min at 1 or 2 min and correlated negatively with basal oxygen saturation at 1 min. Heart rate at 1 min, correlated negatively with final oxygen saturation (p < 0.01). Statistically significant negative correlations were also observed between red cell count and white blood cell count and HOMA-IR with a p < 0.01. Since discrete hematological but significant changes correlated with HRR and HRR-derived parameters, we consider that these measures are helpful in clinical settings to identify subclinical autonomic dysfunction that permits us to prevent or anticipate chronic and fatal clinical outcomes. MDPI 2021-11-24 /pmc/articles/PMC8699903/ /pubmed/34943423 http://dx.doi.org/10.3390/diagnostics11122187 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aztatzi-Aguilar, O. Gamaliel Vargas-Domínguez, Claudia Debray-Garcia, Yazmin Ortega-Romero, Manolo S. Almeda-Valdés, Paloma Aguilar-Salinas, Carlos A. Naranjo-Meneses, M. Augusta Mena-Orozco, D. Abril Lam-Chung, César E. Cruz-Bautista, Ivette Sierra-Vargas, M. Patricia Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
title | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
title_full | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
title_fullStr | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
title_full_unstemmed | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
title_short | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
title_sort | biochemical and hematological relationship with the evaluation of autonomic dysfunction by heart rate recovery in patients with asthma and type 2 diabetes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699903/ https://www.ncbi.nlm.nih.gov/pubmed/34943423 http://dx.doi.org/10.3390/diagnostics11122187 |
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