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Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort

At the moment, several COVID-19 scoring systems have been developed. It is necessary to determine which one better predicts a poor outcome of the disease. We conducted a single-center prospective cohort study to validate four COVID-19 prognosis scores in adult patients with confirmed infection at wa...

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Autores principales: Gil-Rodríguez, Jaime, Martos-Ruiz, Michel, Peregrina-Rivas, José-Antonio, Aranda-Laserna, Pablo, Benavente-Fernández, Alberto, Melchor, Juan, Guirao-Arrabal, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699931/
https://www.ncbi.nlm.nih.gov/pubmed/34943448
http://dx.doi.org/10.3390/diagnostics11122211
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author Gil-Rodríguez, Jaime
Martos-Ruiz, Michel
Peregrina-Rivas, José-Antonio
Aranda-Laserna, Pablo
Benavente-Fernández, Alberto
Melchor, Juan
Guirao-Arrabal, Emilio
author_facet Gil-Rodríguez, Jaime
Martos-Ruiz, Michel
Peregrina-Rivas, José-Antonio
Aranda-Laserna, Pablo
Benavente-Fernández, Alberto
Melchor, Juan
Guirao-Arrabal, Emilio
author_sort Gil-Rodríguez, Jaime
collection PubMed
description At the moment, several COVID-19 scoring systems have been developed. It is necessary to determine which one better predicts a poor outcome of the disease. We conducted a single-center prospective cohort study to validate four COVID-19 prognosis scores in adult patients with confirmed infection at ward. These are National Early Warning Score (NEWS) 2, Lung Ultrasound Score (LUS), COVID-19 Worsening Score (COWS), and Spanish Society of Infectious Diseases and Clinical Microbiology score (SEIMC Score). Our outcomes were the combined variable “poor outcome” (non-invasive mechanical ventilation, intubation, intensive care unit admission, and death at 28 days) and death at 28 days. Scores were analysed using univariate logistic regression models, receiver operating characteristic curves, and areas under the curve. Eighty-one patients were included, from which 21 had a poor outcome, and 9 died. We found a statistically significant correlation between poor outcome and NEWS2, LUS > 15, and COWS. Death at 28 days was statistically correlated with NEWS2 and SEIMC Score although COWS also performs well. NEWS2, LUS, and COWS accurately predict poor outcome; and NEWS2, SEIMC Score, and COWS are useful for anticipating death at 28 days. Lung ultrasound is a diagnostic tool that should be included in COVID-19 patients evaluation.
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spelling pubmed-86999312021-12-24 Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort Gil-Rodríguez, Jaime Martos-Ruiz, Michel Peregrina-Rivas, José-Antonio Aranda-Laserna, Pablo Benavente-Fernández, Alberto Melchor, Juan Guirao-Arrabal, Emilio Diagnostics (Basel) Article At the moment, several COVID-19 scoring systems have been developed. It is necessary to determine which one better predicts a poor outcome of the disease. We conducted a single-center prospective cohort study to validate four COVID-19 prognosis scores in adult patients with confirmed infection at ward. These are National Early Warning Score (NEWS) 2, Lung Ultrasound Score (LUS), COVID-19 Worsening Score (COWS), and Spanish Society of Infectious Diseases and Clinical Microbiology score (SEIMC Score). Our outcomes were the combined variable “poor outcome” (non-invasive mechanical ventilation, intubation, intensive care unit admission, and death at 28 days) and death at 28 days. Scores were analysed using univariate logistic regression models, receiver operating characteristic curves, and areas under the curve. Eighty-one patients were included, from which 21 had a poor outcome, and 9 died. We found a statistically significant correlation between poor outcome and NEWS2, LUS > 15, and COWS. Death at 28 days was statistically correlated with NEWS2 and SEIMC Score although COWS also performs well. NEWS2, LUS, and COWS accurately predict poor outcome; and NEWS2, SEIMC Score, and COWS are useful for anticipating death at 28 days. Lung ultrasound is a diagnostic tool that should be included in COVID-19 patients evaluation. MDPI 2021-11-26 /pmc/articles/PMC8699931/ /pubmed/34943448 http://dx.doi.org/10.3390/diagnostics11122211 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gil-Rodríguez, Jaime
Martos-Ruiz, Michel
Peregrina-Rivas, José-Antonio
Aranda-Laserna, Pablo
Benavente-Fernández, Alberto
Melchor, Juan
Guirao-Arrabal, Emilio
Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort
title Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort
title_full Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort
title_fullStr Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort
title_full_unstemmed Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort
title_short Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort
title_sort lung ultrasound, clinical and analytic scoring systems as prognostic tools in sars-cov-2 pneumonia: a validating cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699931/
https://www.ncbi.nlm.nih.gov/pubmed/34943448
http://dx.doi.org/10.3390/diagnostics11122211
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