Cargando…

Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study

In order to assess coronary artery calcium (CAC) quantification reproducibility for photon-counting computed tomography (PCCT) at reduced tube potential, an anthropomorphic thorax phantom with low-, medium-, and high-density CAC inserts was scanned with PCCT (NAEOTOM Alpha, Siemens Healthineers) at...

Descripción completa

Detalles Bibliográficos
Autores principales: van der Werf, Niels R., van Gent, Margo, Booij, Ronald, Bos, Daniel, van der Lugt, Aad, Budde, Ricardo P. J., Greuter, Marcel J. W., van Straten, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699960/
https://www.ncbi.nlm.nih.gov/pubmed/34943428
http://dx.doi.org/10.3390/diagnostics11122192
_version_ 1784620640548945920
author van der Werf, Niels R.
van Gent, Margo
Booij, Ronald
Bos, Daniel
van der Lugt, Aad
Budde, Ricardo P. J.
Greuter, Marcel J. W.
van Straten, Marcel
author_facet van der Werf, Niels R.
van Gent, Margo
Booij, Ronald
Bos, Daniel
van der Lugt, Aad
Budde, Ricardo P. J.
Greuter, Marcel J. W.
van Straten, Marcel
author_sort van der Werf, Niels R.
collection PubMed
description In order to assess coronary artery calcium (CAC) quantification reproducibility for photon-counting computed tomography (PCCT) at reduced tube potential, an anthropomorphic thorax phantom with low-, medium-, and high-density CAC inserts was scanned with PCCT (NAEOTOM Alpha, Siemens Healthineers) at two heart rates: 0 and 60–75 beats per minute (bpm). Five imaging protocols were used: 120 kVp standard dose (IQ level 16, reference), 90 kVp at standard (IQ level 16), 75% and 45% dose and tin-filtered 100 kVp at standard dose (IQ level 16). Each scan was repeated five times. Images were reconstructed using monoE reconstruction at 70 keV. For each heart rate, CAC values, quantified as Agatston scores, were compared with the reference, whereby deviations >10% were deemed clinically relevant. Reference protocol radiation dose (as volumetric CT dose index) was 4.06 mGy. Radiation dose was reduced by 27%, 44%, 67%, and 46% for the 90 kVp standard dose, 90 kVp 75% dose, 90 kVp 45% dose, and Sn100 standard dose protocol, respectively. For the low-density CAC, all reduced tube current protocols resulted in clinically relevant differences with the reference. For the medium- and high-density CAC, the implemented 90 kVp protocols and heart rates revealed no clinically relevant differences in Agatston score based on 95% confidence intervals. In conclusion, PCCT allows for reproducible Agatston scores at a reduced tube voltage of 90 kVp with radiation dose reductions up to 67% for medium- and high-density CAC.
format Online
Article
Text
id pubmed-8699960
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86999602021-12-24 Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study van der Werf, Niels R. van Gent, Margo Booij, Ronald Bos, Daniel van der Lugt, Aad Budde, Ricardo P. J. Greuter, Marcel J. W. van Straten, Marcel Diagnostics (Basel) Article In order to assess coronary artery calcium (CAC) quantification reproducibility for photon-counting computed tomography (PCCT) at reduced tube potential, an anthropomorphic thorax phantom with low-, medium-, and high-density CAC inserts was scanned with PCCT (NAEOTOM Alpha, Siemens Healthineers) at two heart rates: 0 and 60–75 beats per minute (bpm). Five imaging protocols were used: 120 kVp standard dose (IQ level 16, reference), 90 kVp at standard (IQ level 16), 75% and 45% dose and tin-filtered 100 kVp at standard dose (IQ level 16). Each scan was repeated five times. Images were reconstructed using monoE reconstruction at 70 keV. For each heart rate, CAC values, quantified as Agatston scores, were compared with the reference, whereby deviations >10% were deemed clinically relevant. Reference protocol radiation dose (as volumetric CT dose index) was 4.06 mGy. Radiation dose was reduced by 27%, 44%, 67%, and 46% for the 90 kVp standard dose, 90 kVp 75% dose, 90 kVp 45% dose, and Sn100 standard dose protocol, respectively. For the low-density CAC, all reduced tube current protocols resulted in clinically relevant differences with the reference. For the medium- and high-density CAC, the implemented 90 kVp protocols and heart rates revealed no clinically relevant differences in Agatston score based on 95% confidence intervals. In conclusion, PCCT allows for reproducible Agatston scores at a reduced tube voltage of 90 kVp with radiation dose reductions up to 67% for medium- and high-density CAC. MDPI 2021-11-25 /pmc/articles/PMC8699960/ /pubmed/34943428 http://dx.doi.org/10.3390/diagnostics11122192 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
van der Werf, Niels R.
van Gent, Margo
Booij, Ronald
Bos, Daniel
van der Lugt, Aad
Budde, Ricardo P. J.
Greuter, Marcel J. W.
van Straten, Marcel
Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study
title Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study
title_full Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study
title_fullStr Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study
title_full_unstemmed Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study
title_short Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study
title_sort dose reduction in coronary artery calcium scoring using mono-energetic images from reduced tube voltage dual-source photon-counting ct data: a dynamic phantom study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699960/
https://www.ncbi.nlm.nih.gov/pubmed/34943428
http://dx.doi.org/10.3390/diagnostics11122192
work_keys_str_mv AT vanderwerfnielsr dosereductionincoronaryarterycalciumscoringusingmonoenergeticimagesfromreducedtubevoltagedualsourcephotoncountingctdataadynamicphantomstudy
AT vangentmargo dosereductionincoronaryarterycalciumscoringusingmonoenergeticimagesfromreducedtubevoltagedualsourcephotoncountingctdataadynamicphantomstudy
AT booijronald dosereductionincoronaryarterycalciumscoringusingmonoenergeticimagesfromreducedtubevoltagedualsourcephotoncountingctdataadynamicphantomstudy
AT bosdaniel dosereductionincoronaryarterycalciumscoringusingmonoenergeticimagesfromreducedtubevoltagedualsourcephotoncountingctdataadynamicphantomstudy
AT vanderlugtaad dosereductionincoronaryarterycalciumscoringusingmonoenergeticimagesfromreducedtubevoltagedualsourcephotoncountingctdataadynamicphantomstudy
AT buddericardopj dosereductionincoronaryarterycalciumscoringusingmonoenergeticimagesfromreducedtubevoltagedualsourcephotoncountingctdataadynamicphantomstudy
AT greutermarceljw dosereductionincoronaryarterycalciumscoringusingmonoenergeticimagesfromreducedtubevoltagedualsourcephotoncountingctdataadynamicphantomstudy
AT vanstratenmarcel dosereductionincoronaryarterycalciumscoringusingmonoenergeticimagesfromreducedtubevoltagedualsourcephotoncountingctdataadynamicphantomstudy